Prof. D. Syiem

Biochemistry Department

Designation: Professor

Qualifications:

NET (JRF, UGC-CSIR), MSc, NEHU (1984)., Ph.D (1996), Biochemistry, NEHU?

Present position : Professor, w.e.f  Dec, 2009, Department of Biochemistry 1st Jan, 2009 as Professor

Research Expertise/ Interests:     
Enzymology, Techniques in Biochemistry; Medical Biochemistry; Diabetes; Natural products; Medicinal Plants; Ethnopharmacology.

Experience/ positions held :

  • More than 25 years of Teaching and Research, Professor, since 2009,
  • Head of Dept: 2014-2017.

Papers  published :    58;   Books: 01;  Abstracts: 49;        Technical reports:     04       

Research Projects undertaken: Completed:      10        Current project - Nil

Research Guidance: Fourteeen (14) research scholars have received their Doctorates (Ph.D) under my supervision/joint supervision. Three- ongoing.

Seminar, Conferences, Symposia, Workshops, Refresher courses: Participated/ Organized/ Speaker / resource pers>

Member of different Statutory Bodies of the University such as Board of Studies, School Board, Board of Research Studies, Academic Council, University Court, Governing Bodies of different Colleges within the State and outside etc.

Participation in other Developmental Bodies:

  1. Member of National Biodiversity Strategy and Action Plan (NBSAP), State Steering Committee, Meghalaya. 2001-2002.
  2. Member of State Level Planning Committee on Conservation and Sustainable Utilization of Medicinal Plants, Meghalaya. 2003.
  3. Member, Board of Directors, Meghalaya Tourism Development Corporation (MTDC), Govt. of Meghalaya.(2003-2005)
  4. Member, Health Advisory Board, Govt of Meghalaya (2004-2005).
  5. Member, purchase committee, Bio-Resource Development Centre, Govt. of Meghalaya, Shillong (2004-05).
  6. Member, Internal Quality Assurance Cell (IQAC), St. Anthony’s College, Shillong, Oct, 2006-09.
  7. Member, Doctoral Committee, Martin Luther Christian University, Shillong Nov. 2006-09.
  8. Member, Governing Body, State Medicinal Plant Board, Meghalaya, 2006.
  9. Member, Resource Group on Medicinal Plants, Bio-Resources Development Centre (BRDC), Govt. of Meghalaya, 2008.
  10. Counseling member for MBBS, PG admission and Nursing of North East Indira Gandhi Regional Institute of Medical Science (NEIGRIMS), 2009-10.
  11. Member (VC’s nominee), Governing Body, State Medicinal Plant Board, Meghalaya, 2010-2011.
  12. Member, Khasi Traditional Medicine Commission under the Khasi Hills Autonomous District Council (KHADC), under the Sixth Schedule to the Constitution of India, published in the Gazette of Meghalaya, 14th March, 2012. Period 2019-2020.
  13. Counseling member for MBBS, PG admission and Nursing of North East Indira Gandhi Regional Institute of Medical Science (NEIGRIMS), 2013-14.
  14. Member, Advisory Committee, St Anthony’s College Star College Scheme under DBT, 2015-16.
  15. Member, Meghalaya State Pollution Control Board, 2015-16.
  16. Member, Examination Committee for MBBS selection, Govt. of Meghalaya, 2015-16.
  17. Member screening committee of the Directorate of Higher & Technical Education, Govt. of Meghalaya, for placement of Govt. College Lecturers (2015).
  18. Member, of the Biotech Hub Advisory Board, Lady Keane College, 2015.
  19. Member, State Level Expert Appraisal Committee (SEAC) for Environmental Impact Assessment, Govt. of Meghalaya, (August 2015 to Aug, 2018) and from (Nov, 2018 to Nov 2021).
  20. Editorial Board Member, Bodoland University, open an online science journal entitled “Bio-Science Letters” (bi-annual), 2015-16.
  21. Member, Governing Body, Nabon Women’s Synod College 2015 -2017.
  22. Member, Governing Body, Mairang Science college College 2016 -2018.
  23. Board of Studies in North Eastern Institute of Ayurveda Homoeopathy (NEIAH), for three years w.e.f 15 -2 2017 to 2019.
  24. Member, Editorial board for the quarterly journal “ Science Vision; ISSN (online) 22296026, Mizo Academy of Sciences, Aizawl, Mizoram, 15th Feb.2017 onwards.
  25. Member, Research Advisory Board of the North East Cancer Hospital and Research Institute (NECHRI). Jorabat, Guwahati, Assam. W.e.f  June 2017.
  26. Member, BOS Royal Global University, Ghy, Assam. For two years 2019-2020.

Membership and Affiliations to Professional Bodies/Societies, etc.

  • Meghalaya Science Society, Shillong, India.
  • Life member, Association of Gerontology, India.
  • Founding Member and President, Biochemistry Alumni Association, 2005. NEHU, Shillong.
  • Vice President, North Eastern Hill University Teaching Association (NEHUTA), NEHU, Shillong, 2005-2006.
  • Joint Secretary, Meghalaya Tribal Teachers Association, 2004-05.
  • Executive Member, Synkhong Kyntiew Ri, 2004-05, Shillong.
  • Founding Member and joint secretary, St. Anthony’s College Shillong alumni association (SACSA), 2005-2008.
  • Life member Association of Analytical Scientist, regional chapter.
  • Founding Member and Advisor, North East Wisdom on Human Existence And Local Traditions of Health (NEW HEALTH) 2008, An Association of Local Health Traditional Practitioners, Shillong, Meghalaya.
  • Life member, Indian Science Congress Association (L 13848), 2008.
  •  Life member, Shillong Agri-Horticultural Society, from 2009.
  •  Joint Secretary, Association of Gerontology, India, 2010-2011.
  • President, NEHU Alumni Association ad hoc  2012 till 2014.
  • Council member, Association of Gerontology, India, 2012-2014.
  • President, NEHU Alumni Association and founding member  2014-till April 2019.
  • Executive Member, NEHUTA  2019-2020.

Publications

International

  1. Syiem D, & Sharma R. (1997). Age- and Tissue specific regulation of chicken inorganic pyrophosphatase in Biochemistry and Molecular Biology International, vol 42, pp. 809-815
  2. Syiem. D, Syngai. G, Khup. P. Z, Khongwir. B. S, Kharbuli. B and Kayang. H. (2002). Hypoglycemic effects of Potentilla fulgens L. in normal and alloxan-induced diabetic mice. J. Ethnopharmacology 83: 55-61 (IF= 3.115)
  3. Kayang. H, Kharbuli. B, Myrboh. B, and Syiem. D. (2005). Medicinal Plants of Meghalaya. In Bioprospecting & Ethnopharmacology a proceedings of The 3rd World Congress on Medicinal and Aromatic Plants for Human Welfare (WOCMAP III) held at Chiang Mai, Thailand on 3-7 February 2003. Acta Horticulturae, 675: 75-80
  4. Syiem D and Khup P. Z. (2006). Study of traditionally used medicinal plant Osbeckia chinensis for hypoglycemic and anti-hyperglycemic effects in mice: Pharmaceutical Biology, 44: 613-618 (IF=1.62).
  5. Syiem D and Khup P.Z. (2007). Evaluation of Flemingia macrophylla L., A traditionally used plant of the north eastern region of India for hypoglycemic and anti-hyperglycemic effect on mice. Pharmacologyonline, 2: 355-366
  6. Syiem D, Khup P.Z. & Syiem A.B. (2008). Evaluation of anti-diabetic potential of Albizzia lebbek bark in normal and alloxan-induced diabetic mice. Pharmacologyonline, 3: 563-573.
  7. Syiem D, P Z. Khup, and Syiem A.B. (2009). Effects of Potentilla fulgens Linn. on carbohydrate and lipid profiles in diabetic mice. Pharmacologyonline, 2: 787-795.
  8. Syiem D & Lyngdoh W (2009). Hypoglycemic effects of Gymnopetalum Cochinchinensis. Pharmacologyonline, 2:728-738 (IF=0.165)
  9. Syiem D, Sharma R & Saio V (2009) In vitro study of the antioxidant potential of some traditionally used medicinal plants of North-East India and assessment of their total phenolic content. Pharmacologyonline, 3:952-965.
  10. Syiem D and Majaw S (2010). Effect of Potentilla fulgens L. on Aldose Reductase activity of  normal and diabetic mice. Inventi Rapid: Ethnopharmacology Vol. 1, Issue 1, www.inventi.in.
  11. Syiem D and Majaw S (2010). Effect of Potentilla fulgens L. methanolic extract on Sorbitol Dehydrogenase in normal and alloxan-induced diabetic mice. Pharmacologyonline, 2:671-680.
  12. Roy B, Swargiary A, Syiem D and Tandon, V (2010). Potentilla fulgens (Family Rosaceae), a medicinal plant of North-East India: a natural anthelmintic?", Journal of Parasitic Diseases, 34: 83-88
  13. Syiem D, Monsang Sh. W and Sharma R (2010). Study of the hypoglycemic and anti-hyperglycemic activity of curcuma amada roxb. in normal and alloxan induced diabetic mice. Pharmacologyonline 3: 364-372.
  14. Syiem D and Warjri P (2011). Hypoglycemic and antihyperglycemic effects of aqueous extract of Ixeris gracilis DC. on normal and alloxan-induced diabetic mice. Diabetologica Croatica. 40(3), 89-95.
  15. Syiem D & Majaw S (2011). Effect of different solvent extracts of Potentilla fulgens L. on aldose reductase and sorbitol dehydrogenase in normoglycemic and diabetic mice. Pharmacologyonline, 3: 63-72.
  16. Saio V, Syiem D & Sharma R (2012). Effect of Potentilla fulgens on lipid peroxidation and antioxidant status in alloxan-induced diabetic mice. Journal of Basic and Clinical Pharmacy. 3:249-253
  17. Syiem D & Lyngdoh W (2013). Glyco-and Lipo-regulatory effects of Gymnopetalum cochinchinense(Lour) Kurz in alloxan-induced diabetic mice. The Journal of Ethnobiology and Traditional Medicine. The Journal of Ethnobiology and Traditional Medicine. Photon 118 (2013) 214-221.
  18. Syiem D and Warjri P (2013). The Effect of Aqueous extract on Smilax perfoliata on blood  glucose, lipids and selected hepatic enzymes of alloxan- induced diabetic mice. Int. J Pharm Bio Sci. 4(2) pp. 945-955.
  19. Syiem D and Warjri P (2015). Antidiabetic, antioxidant and TNF- α lowering properties of extract of the traditionally used plant Ixeris gracilis in alloxan-induced diabetic mice (http://informahealthcare.com/phb; DOI: 10.3109/13880209.2014.924151; Pharmaceutical Biology online 1-9) (IF = 1.62) Pharm Biol, 2015 53(4): 494-502.
  20. Saio V, Syiem D, Sharma R & Dkhar J (2016). Amelioration of age-dependent increase in oxidative stress markers in male mice by extract of Potentilla fulgens (Redox Report, online Communications in free Radicals)). http://dx.doi.org/10.1179/1351000215Y.0000000006. Redox Rep. 21,130-138. (IF=1.963).    
  21. Patar A K, Bhan S & Syiem D (2016). Effect of chlorophyllin, an semi-symthetic chlorophyll molecule on hyperglycemia and hyperlipidemia in streptozotocin induced diabetic mice. Int. J of Pharmacy & Pharmaceutical Sciences, 8(8):293-296. (IF=0.5)
  22. Majaw S & Syiem D (2016). Effect of Osbeckia Chinensis root extract on aldose reductase and sorbitol dehydrogenase activity in mice of two different age groups. Der Pharmacia Lettre, 8 (13):149-156.(IF= 0.42)
  23. Patar A K, Bhan S, Syiem D & Sharma A (2016). Ameliorative effect of chlorophyllin on oxidative stress in experimental model of diabetes. Intl. J of Phytomedicine (8): 506-513 (IF = 1.23)
  24. Rynjah CV, Devi NN, Khongthaw N, Syiem D & Majaw S (2017). Evaluation of the antidiabetic property of aqueous leaves extract of Zanthoxylum armatum DC. using in vivo and in vitro approaches. Journal of Traditional and Complementary Medicine. http://dx.doi.org/10.1016/j.jtcme.2017.04.007. http://www.elsevier.com/locate/j tcme (RG IF=2.37, SJR IF = 0.5)
  25. Barilin Dkhar, Kitboklang Khongsti, Daiahun Thabah, Donkupar Syiem, Kapaettu Satyamoorthy and Bidyadhar Das (2017). Genistein Represses PEPCK-C Expression In An Insulin-Independent Manner In HepG2 Cells And In Alloxan-Induced Diabetic Mice. Journal of Cellular Biochemistry (John Wiley & Sons, Inc) pp. 1-61 (IF=3.45). J Cell Biochem. 2018;119:1953–1970.
  26. Patar, A.K., Sharma, A., Syiem D., & Bhan, S. (2018). "Chlorophyllin supplementation modulates hyperglycemia-induced oxidative stress and apoptosis in liver of streptozotocin-administered mice". BioFactors (Wileyhttps://doi.org/10.1002/biof.1438.), 44(5):418-430.(IF= 3.598) .
  27. Suktilang Majaw Sooni Kerki Challam Donkupar Syiem (2018). Effect of Potentilla Fulgens L. on Selected Enzyme Activities and Altered Tissue Morphology in Diabetic Mice. J Morphol Sci 2018;35:153–160
  28. Lanong S et al., (2019). Culture-dependent and metagenomic analysis of lesser horseshoe bats’ gut microbiome revealing unique bacterial diversity and signatures of potential human pathogens. In Press, Journal: Microbial Pathogenesis (IF=2.58).

National:

  1. Syiem D., & Sharma R. (1996). Purification and kinetic characterisation of chicken liver inorganic pyrophosphatase, Indian Journal of Biochemistry and Biophysics , vol 33, pp. 363-370
  2. Syiem. D, Syngai. C, Kharbuli. B, Kayang. H and Khongwir. B. S. (2003). Anti-Tumour Activity of Crude Root Extract of Potentilla fulgens. Indian Drugs 40 (2): 124-125
  3. Laskar. M. A, Lyngdoh. J. P, Buam. J. J, and Syiem. D. (2005). Plantlet regeneration via adventitious shoot bud proliferation from leaf explants in Potentilla fulgens Wall.ex Hook.- A plant possessing hypoglycemic activity. Indian Journal of Biotechnology, 4: 257-260
  4. Laskar. M. A, Lyngdoh. J. P, and Syiem. D (2006). Induction of Callus Cultures in Panax assamica; Journal of Applied Biosciences and Biotechnology, 2: 63-66
  5. Kayang H, Kharbuli B and Syiem D (2007). Role of Community in Conservation of Biodiversity: a Case Study in Khasi Hills of Meghalaya, India. Journal of Basic & Applied Biology 1: 1-5
  6. Kayang H, Kharbuli B and Syiem D (2008). Gaultheria fragrantissima Wall.- An untapped economic plants species of Meghalaya. Natural Product Radiance, Vol 7(5), p 400.
  7. Kayang H, Kharbuli B and Syiem D (2009). Litsea Wall.- An untapped economic plants species of Meghalaya. Natural Product Radiance, Vol, No 8(1), p 5
  8. Sharma R and Syiem  D (2013).Goals towards healthy ageing. Current Science, Vol. 104.
  9. Lyngdoh JP, Syiem D & Mao AA (2014). Pattern of traditional medicine usage in East Khasi Hills of Meghalaya. Indian Journal of Traditional Knowledge, Vol. 13 (1),  pp. 164-170.
  10. J J H. Anal, R Majeed, G Bez, D Syiem, A Hamid and A K. Saxena (2014) . In vitro cytotoxicity of the polar extracts of Potentilla fulgens L. against human cancer cell lines: Detection and isolation of bioactive phenolics. Journal of chemical and pharmaceutical research vol 6(9): 89-95.
  11. Saio V. and Syiem D (2015). Phytochemical analysis of some traditionally used medicinal plants of North-east India. Journal of Science and Environment Today. Vol.1: 6-13
  12. Majaw S & Syiem D (2016). In vitro aldose reductase inhibitory potential of fractions isolated from Potentilla fulgens roots. J of Applied Pharmaceutical Science, Vol 6: 102-109.
  13. Jutishna Bora, Donkupar Syiem & Surya Bhan (2018). Methanolic flower extract of Phlogacanthus thyrsiflorus nees attenuates diabetic nephropathy in alloxan-induced diabetic mice. Asian J Pharm Clin Res, Vol 11, Issue 7, 2018, 1-4
  14. Jutishna Bora, Plabita Sahariah, Abani Kumar Patar, Donkupar Syiem & Surya Bhan (2018). Attenuation of diabetic hepatopathy in alloxan-induced diabetic mice by methanolic flower extract of Phlogacanthus thyrsiflorus Nees. Journal of Applied Pharmaceutical Science Vol. X(XX), pp XX-XX, 2018 . Available online at http://www.japsonline.com .DOI: ISSN 2231-3354
  15. Plabita Sahariah, Jutishna Bora, Donkupar Syiem & Surya Bhan (2018) Effect of dillenia indica l. against oxidative stress-induced cardiomyopathy on alloxan-induced diabetes mice model. Asian J Pharm Clin Res (http://creativecommons.org/licenses/by/4. 0/) DOI: http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26636.
  16. Plabita Sahariah, Jutishna Bora, Abani Kumar Patar Donkupar Syiem & Surya Bhan (2018) Evaluation of antihyperglycemic and antioxidative effects of Dillenia indica l. using in vivo approaches. Int. J of Pharmaceutical and Research (IJPSR), Vol. 9(11): 1000-12.
  17.   Sheryl Lanong, Ferry Kharshandi, Highland Kayang, Donkupar Syiem (2018) Report On Isolation Of Plant Growth Promoting Bacteria (PGPB) From The Gut Of Lesser Horseshoe Bat Collected From The North-Eastern Part Of India., International Journal of Advanced Scientific Research and Management, (IJASRM)  Vol 3 Issue 12, Dec 2018, pp 78-89.
  18. Bora J, Syiem D and Bhan S (2019)  Quantitative analysis of total phenolic, flavonoid contents and HPTLC fingerprinting of flower extracts of Phlogacanthus thyrsiflorus Nees.  Journal of Pharmacognosy and Phytochemistry (JPP); 8(3): 906-911.

Proceedings/book chapters etc:

  1. Syiem D, & Sharma R. Kinetic differences in liver inorganic pyrophosphatase during development of chick,  in : Aging, Indian perspective and Global Scenario (ed. V.Kumar) pp. 445-458., Balaji printers as part of the proceedings of the International Symposium on Gerontology (India), and VIIth. conference of the Association of Gerontology (India), held at the All India Institute of Medical Sciences, AIIMS, New Delhi, 1994, from  14th - 16th November
  2. Nongkhlaw D.G., Das B, Syiem D, Kharbuli B, Myrboh B, Kayang H, and. Buam D.R.M, (1999). Biodiversity Conservation: What it means to the People: A case study of the Mawphlang Dam. In Proceedings Biodiversity, North East India Perspectives.  (Eds. B. Kharbuli, D. Syiem and H. Kayang)  pp- 121- 127
  3. Syiem D., Kharbuli B, Khongwir B.S, Kayang H and Myrboh B. Prospect of Ethno-botany in North Eastern India, paper presented in National Seminar on Ethnobotany: Past, Present and Future held at Aizawl, Mizoram on the 12th April 2000.
  4. Syiem D, Joshi S.R. and Syiem M.B (2005). Intellectual Property Rights and North East India- issues and relevance: Proceedings of the National Seminar on Intellectual Property Rights, published by St Anthony’s College, Shillong , pp. 145-149
  5. Syiem D, Kharbuli B, Myrboh B, and Buam. D.R.M. (2006). Medicinal Plants and Herbal Medicine: A case study in Meghalaya. In Biodiversity in North East India.  Eds. B. Kharbuli, H. Kayang and D. Syiem - pp- 51-59. NEHU Publication.
  6. Kharbuli B., Syiem D, and Nongkhlaw D.G (2006).  The Socio-cultural Evolution of Sacred Groves among the Khasis of Meghalaya, In Biodiversity in North East India.  Eds. B. Kharbuli, H. Kayang and D. Syiem - pp- 217 – 221. NEHU Publication.
  7. Syiem D, Kayang H, Mawthoh P.R. and Kharbuli B (2006). Indigenous Knowledge System with Special Reference to the Khasis of Meghalaya. In Biodiversity in North East India.  Eds. B. Kharbuli, H. Kayang and D. Syiem - pp- 209 - 212 NEHU Publication.
  8. Mawthoh P. R., Syiem D. & Kharbuli B (2006); Traditional Land Tenure System of the Khasis of Meghalaya, India. In Biodiversity in North East India.  Eds. B. Kharbuli, H. Kayang and D. Syiem - pp- 213 - 216. NEHU Publication.
  9. Syiem D and Syiem M.B (2007).  Medicinal plants and conservation: some issues and concerns. In Biodiversity and its significance. Eds. P.Tandon, Y.P. Abrol and S. Kumaria. pp. 151-156 I.K International Publishing House Pvt. Ltd, New Delhi
  10. Majaw S and Syiem D (2008) Medicinal plants: potential source in the treatment of diabetes. In Biodiversity: Herbal Medicine. Eds. Marngar D and Jyrwa S. p 204-210. Akansha Publishing House, New Delhi.
  11. Syiem, D. (2010). Medicinal and Aromatic plants: Role in health, Economy and Biodiversity Conservation.  In Indigenously Yours (Eds: B.K Sohliya & P.J.Dutta) Proceedings of the Workshop on Conserving and Promoting Biodiversity: Strategic approaches, organized and published by the Directorate of Horticulture, Govt. of Meghalaya on 6th October,2010.
  12. Syiem D, Lyngdoh W, Warjri  P,  Tariang D, Dkhar  A & Deingdoh A.M.R (2012). Prevalence of diabetes amongst the Khasi and Jaintia population of Meghalaya. The NEHU Journal, Vol X, No.1, 73-80.

Books

  1. Biodiversity in North East India (ed.  B. Kharbuli, H. Kayang & D Syiem). Published by NEHU publication, 2006.

Reviewer and member Editorial Board of different National and International Journals:

  • Editorial Board Member for publication of booklets on environment, published by the Assam Science Society, 2004-05.
  • Editorial board member for the Journal of Applied Bioscience & Biotechnology, Assam, 2005-2007.
  • Science Alert. support@scialert.com , 2009-10
  • Reviewer for African Journal of Pharmacy and Pharmacology (AJPP). E-Mail: ajpp.academicjournals@gmail.com. http://www.Academicjournals.Org/AJPP, 2009-10
  • Reviewer for Journal of Agricultural Biotechnology and Sustainable Development, www.academicjournals.org/JABSD, 2009-2010
  • Reviewer for Journal of Medicinal Plants Research.  www.academicjournals.org/jmpr, ISSN 1996-0875;  2010-11.
  • Reviewer : Science Alert. support@scialert.com , 2009-10.
  • Reviewer for African Journal of Pharmacy and Pharmacology (AJPP). E-Mail: ajpp.academicjournals@gmail.com. http://www.Academicjournals.Org/AJPP, 2009-10
  • Reviewer for Journal of Agricultural Biotechnology and Sustainable Development, www.academicjournals.org/JABSD, 2009-2010
  • Reviewer for Journal of Medicinal Plants Research.  www.academicjournals.org/jmpr, ISSN 1996-0875;  2010-11
  • Reviewer : Pharmaceutical Biology, Taylor & Francis , 2016.
  • Member, Editorial board for the quarterly journal “ Science Vision; ISSN (online) 22296026, Mizo Academy of Sciences, Aizawl, Mizoram, 15th Feb.2017 onwards
  • Editorial Board Member, Bodoland University, open an online science journal entitled “Bio-Science Letters” (bi-annual), 2015-16.
  • Reviewer : Pharmaceutical Biology, Taylor & Francis , 2016.
  • Member, Editorial board for the quarterly journal “ Science Vision; ISSN (online) 22296026, Mizo Academy of Sciences, Aizawl, Mizoram, 15th Feb.2017 onwards
  • Reviewer: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science, 2019.
  • Reviewer : BMC Complementary and Alternative Medicine journal, Springer Nature, 2018 -2019

Any Other:

Has carried out projects and established collaboration with NEC, MoEF, Govt of Meghalaya through NBSAP, NEBRC, KHADC, BRDC, other institutions and universities of the North East Region of India.