Prof. R. Sharma

Biochemistry Department

Designation: Professor

Qualifications:

  • B.Sc. (1976) BHU, Varanasi
  • M.Sc. (1978) BHU
  • Ph.D. (1981) BHU

Prof. Ramesh Sharma has been teaching various disciplines of physiology and biochemistry for more than three decades, mostly at post-graduate/research levels. Currently, he is a professor of Biochemistry at the North-Eastern Hill University (a central University), Shillong, India. He obtained his graduation (1976), post-graduation (1978) and Ph.D. (1981) degrees from Banaras Hindu University, Varanasi, India. He did his post-doctoral research at the University of California, Berkeley, USA (1986-88) with Prof. Paola S. Timiras.

He started teaching since 1982 as an Assistant Professor (Manipur University) and then as an Associate Professor (1988) and Professor (1998) at the department of Biochemistry, North-Eastern Hill University, Shillong, India. He did his post-doctoral research at the University of California, Berkeley, USA (1986-88); and had been a Visiting Scientist at the Institute of Enzyme Research at Tokushima University, Japan (1989-90) and at Department of Biochemistry at the Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan (2003-04; 2016). He has visited Semmelweis University, Budapest, Hungary under INSA senior scientist exchange programme (2014). He has been on the editorial board of International journals such as ‘Biogerontology’ from Springer, The Netherlands; ‘International Journal of Developmental Neurosciences’ from Elsevier, USA; ‘Okinawa Wellness & Longevity Journal’ Okinawa, Japan; ‘Frontiers in Genetics of Aging’, Science Park, Switzerland. He has more than 95 publications in International and National journals of repute in the field of aging research (mostly on hormonal regulation of enzymes, glucocorticoid receptors and related signaling during aging and their modulation by dietary restriction) and has produced 18 Ph.D.s. In 2008, he has been elected as a Fellow of the National Academy of Sciences (India). He has been the Head of the Department of Biochemistry for three terms (1993-96; 1999-2002; 2011-14) and is presently Coordinator of the UGC-SAP-programme in Biochemistry and the Dean, School of Life Sciences. He was also the Coordinator of the University with Potential for Excellence (UPE) given by UGC to NEHU. He has been member of board of management of NERIST and the research council member of CSIR-RRL (now NEIST), Jorhat, Assam. Prof. Sharma has also been chairman of Board of under- and post-graduate studies in Biochemistry, Home Science and Nursing and also the member of Academic council of NEHU and Mizoram University. He has been the President of Association of Gerontology (India) and is an expert member in Task Force on Neuro-Disease Biology, DBT, GOI (2014-17). He is also member of the State Higher Education Council (SHEC) of Mizoram (2014-20). He has carried-out eight research projects funded by different National and International agencies: i. UGC project entitled “Biochemical adaptations in relation to evolution” (2984-85). ii. Ministry of Education, Japan project entitled “Studies on biomodulators of glucocorticoid action” (1989-90). iii. UGC project entitled “Regulatory changes in enzymes of malate-aspartate shuttle during dev. and aging of mice” (1990-93). iv. DST project entitled “Biochemical changes in glucocorticoid receptor during dev. and aging of mice” (1991-95). v. CSIR project entitled “Regulation of adenosine deaminase in mice: hormonal and dietary interventions” (1999-2002). vi. DST project entitled "Regulation of glucocorticoid receptors during dietary restriction in mice" (2000-2004). vii. UGC project entitled “Dietary and hormonal modulation of protein carbonylation in mice as a function of age” (2009-2012). viii. DST major research project entitled "Studies on biomodulators of glucocorticoid receptor in mice” (2009-2012).

Publications

Research publications (10 only): 

  1. H.S. Ranhotra and R. Sharma (2000) Streptozotocin-induced diabetes and glucocorticoid receptor regulation: tissue- and age-specific variation. Mech. Ageing and Dev.119, 15-24.
  2. D. Dutta and R. Sharma (2004) Age-dependent dietary regulation of glucocorticoid receptors in the liver of mice. Biogerontology 5, 177-184.
  3. R. Sharma, A. Nakamura, R. Takahashi, H. Nakamoto and S. Goto (2006) Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction. Free Radical Biol. Med. 40, 1179-1184.
  4. R. Sharma and D. Dutta (2006) Age-dependent decrease in renal glucocorticoid receptor function is reversed by dietary restriction in mice. Ann. N. Y. Acad. Sci. USA1067, 129-141.
  5. D. Goyary and R. Sharma (2008) Late onset of dietary restriction reverses age-related decline of malate-aspartate shuttle enzymes in the liver and kidney of mice.Biogerontology 9, 11-18.
  6. P. Dkhar and R. Sharma (2010) Effect of dimethylsulphoxide and curcumin on protein carbonyls and reactive oxygen species of cerebral hemispheres of mice as a function of age. Int. J. Devl. Neuroscience 28, 351-357.
  7. P. Dkhar and R. Sharma (2011) Amelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid.Neurochem. Int.59, 996-1002.
  8. P. Dkhar and R. Sharma (2013) Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin. Mol. Cell. Biochem. 380, 153-160.
  9. Dkhar and R. Sharma (2014) Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice. Cell. Mol. Neurobiol.34, 307-313.
  10. I.K.H. Hadem and R. Sharma (2016) Age- and tissue-dependent modulation of IGF-1/PI3K/Akt protein expression by dietary restriction in mice. Horm. Metab. Res. 48, 201-206.