Prof. B. Keshan

Zoology Department

Designation: Professor

Qualifications:

  1. B.Sc. (1989) University of Calcutta, Kolkata
  2. M.Sc. (1991) University of Calcutta, Kolkata
  3. NET (Dec 1991)- Joint CSIR-UGC Test, Life Sciences          
  4. GATE (1992)- Graduate Aptitude Test in Engineering, Basic Sciences and Engineering
  5. Pre-Doctoral Course work (1993) Bose Institute, Kolkata
  6. Ph.D. (1999) University of Calcutta, Kolkata
  7. Post-doc (2003-2005) University of Washington, USA

Areas of Interest/Specialization: Insect Endocrinology and Molecular Biology

  1. Insect hormones and insulin signaling in silkworm, Bombyx mori.
  2. Studies on the involvement of insulin and insect hormones on the carbohydrate metabolism in the silkworm, Bombyx mori.
  3. Studies on the expression of insulin-like peptides, and the role of insulin on vitellogenin mRNA expression and ovarian development in silkworm, Bombyx mori.
  4. Studies on the potential insecticidal activity of identified dsRNA of ecdysone receptor and ecdysone induced early gene, E75 in citrus trunk borer, Pseudonemophas versteegi.
  5. Studies on effect of RNA interference-mediated knockdown of Trehalose-6-phosphate synthase and trehalase genes on carbohydrate reserves and survival of citrus trunk borer, Pseudonemophas versteegii.

Experience:

  1. Junior Research Fellow (JRF-NET, CSIR), 1992-1994, Bose Institute, Kolkata          
  2. Senior Research Fellow (SRF-NET, CSIR), 1994-1997, Bose Institute, Kolkata
  3. Lecturer in Zoology, 1998-2002, City College, Kolkata
  4. Senior Lecturer in Zoology, 2002-2007, City College, Kolkata (on Study leave for 2 years)
  5. Research Associate (Post-doc), 2003-2005, Department of Biology, University of Washington, Seattle, WA, USA
  6. Reader (Zoology), 2007, City College, Kolkata     
  7. Reader (Zoology), 2007-2010, North-Eastern Hill University, Shillong       
  8. Associate Professor (Zoology), 2010-2015, North-Eastern Hill University, Shillong              
  9. Professor (Zoology), 2015- present, North-Eastern Hill University, Shillong           

Awards

  1. Adhiresh Dey Memorial Prize, 1989, Vidyasagar College for Women, Kolkata
  2. First Class Fourth, B.Sc. (Zoology Honours), 1989, University of Calcutta 
  3. First Class Second, 1991, M. Sc. (Zoology), University of Calcutta               
  4. An award under the National Scholarship scheme, Government of India, 1989-1990, on the result of B.Sc. (Zoology) Examination, University of Calcutta    
  5. An award of Junior Research Fellowship, (JRF-NET, CSIR), 1992-1994
  6. An award of Senior Research Fellowship (SRF-NET, CSIR), 1994-1997
  7. Best Oral Presentation 1997, XV National Symposium on Reproductive Biology and Comparative Endocrinology, Hyderabad          
  8. Post-doctoral fellowship, 2003-2005, University of Washington, USA      
  9. Awarded Programme Enhancement Fund (PEF), 2006, Annual Meeting of the Entomological Society of America (ESA) in Indianapolis, USA
  10. DST Fast track Young Scientist Project Award, 2008

Ph.D. Awarded/Supervised

  1. Dr. Bembem Thounaojam: Expression of certain genes involved in insulin signaling in silkworm, Bombyx mori and its hormonal regulation under fed and food deprived conditions ()

Research students currently working for Ph.D. degree

  1. Ms. Kh Sanathoibi Devi: Studies on effects of insulin and insect hormones on carbohydrate metabolism in silkworm, Bombyx mori  in fed and food deprived conditions
  2. Ms. Karen Rowena Rangad Mihsill: Studies on the potential insecticidal activity of identified dsRNA of ecdysone receptors (EcR) and ecdysone-induced early gene E75, in citrus trunk borer, Anoplophora versteegi
  3. Ms. Kanmoni Malakar: Studies on the effect of RNA interference-mediated knockdown of trehalose-6-phosphate synthase and trehalase gene on carbohydrate reserves and survival of citrus trunk borer, Anoplophora versteegi
  4. Mr. Creminar Shira: Studies on the expression of insulin-like peptides, and the role of insulin on vitellogenin mRNA expression and ovarian development in silkworm, Bombyx mori
  5. Ms. Ribhalin Majaw: Registration not yet done

Academic affiliations

  1. Member, Entomological Society of America, 2006
  2. Life Member, Zoological Society, Kolkata, India
  3. Life Member, The Indian Science Congress Association, Kolkata, India

Research Projects

  1. Environmental stress and regulation of gene expression in silkworm (under “genomic instability and environmental stress” group, in School of Life Sciences, NEHU). UGC (Under UPE program) 2007-2011
  2. Molecular aspect of stress endocrinology: cross-talk between signaling molecules and gene expression in fat body and ovary following temperature stress in silkworm, Bombyx mori.  DST (under SERC FAST Track Scheme for Young Scientist). Sanction letter No. SR/FT/LS-026/2008. Department Of Science and Technology, GOI (Order No. SR/FT/LS-026/2008 dated 30.12.2008. Sanctioned Amount: Rs. 16,44,800. 2009-2012.
  3. Insect hormones and insulin signaling in silkworm, Bombyx moriunder fed and starved conditions: a study at molecular level. Department of Biotechnology, GOI (under Basic Research and Emerging Areas) (Order No. BT/PR14289/BRB/10/837/2010). Sanctioned Amount: Rs. 55,73,842. 2011-2014.

Publications

  1. Publications in National/International Journals
    1. Keshan B. and Ray A. K. (1998a). Action of estradiol-17β on the synthetic activity of the silk gland in Bombyx mori L. Journal of Insect Physiology (Pergamon - Elsevier Science Ltd.) 44, 491-498. IF:2.862
    2. Keshan B. and Ray A. K. (1998b). Sub cellular localization of trehalase in different tissues of the silkworm, Bombyx mori L.: Demonstration of the highest activity in mitochondria. Sericologia (International Sericultural Commission) 38(3), 411-418.
    3. Keshan B. and Ray A. K. (2000). Estradiol-17β in Bombyx mori: Possible significance and its effect on silk production. Journal of Insect Physiology (Pergamon - Elsevier Science Ltd.) 46, 1061-1068. IF:2.862
    4. Keshan B. and Ray A. K. (2001a). The presence of estradiol-17β and its specific binding sites in posterior silk gland of Bombyx mori. General and Comparative Endocrinology (Elsevier Inc.) 123, 23-30. IF: 2.445
    5. Keshan B. and Ray A. K. (2001b). Effect of estradiol-17β on cell area, lumen area and the trehalase activity of posterior silk gland of Bombyx mori L. Indian Journal of Experimental Biology 39, 1096-1102. IF: 0.934
    6. Keshan B., Hiruma K. and Riddiford L.M. (2006a).  Developmental expression and hormonal regulation of different isoforms of the transcription factor, E75, in the tobacco hornworm, Manduca sexta. Developmental Biology (Elsevier Inc.) 295, 623-632. IF: 2.936
    7. Keshan B., Hiruma K. and Riddiford L.M. (2006b). Developmental expression and hormonal regulation of the transcription factors, E75C and E75D, in Manduca sexta. Journal of Experimental Zoology Part A-Comparative Experimental Biology (Wiley-Liss, Div John Wiley & Sons Inc.) 305A, 141-141. IF: 1.081
    8. Keshan B. (2011). Molecular basis of endocrine control of insect molting and metamorphosis. NBU J Animal Science 5: 1-8.
    9. Keshan B., Paul S., Thounaojam B. and Devi K. S. (2014). Tissue-specific expression patterns of heat shock protein 90 transcripts in silkworm, Bombyx mori. Journal of Entomology and Zoology Studies, 2: 53-59.
    10. Keshan B., Thounaojam B. and Devi K. S. (2015). A comprehensive study on changes in ecdysteroid levels during feeding phase of fifth larval instar in silkworm, Bombyx mori. European Journal of Entomology. 112: 632–641. IF: 1.167
    11. Paul S. and Keshan B. (2016). Ovarian development and vitellogenin gene expression under heat stress in silkworm, Bombyx mori. Psyche (New York), vol. 2016, Article ID 4242317. doi:10.1155/2016/4242317. IF:0.16
    12. Mihsill K.R.R. and Keshan B. (2017). Ethno-zoological Practices by Khasis, an Indigenous Tribe of Meghalaya, India. NEHU Journal, Vol. XV, p. 89-96. ISSN No. 0972 - 8406
    13. Keshan B., Thounaojam B. and Kh S. D. (2017). Insulin and 20-hydroxyecdysone action in Bombyx mori: Glycogen content and expression pattern of insulin and ecdysone receptors in fat body. General and Comparative Endocrinology (Elsevier Inc.), 241:108-117. IF: 2.445
    14. Thounaojam B. and Keshan, B. (2017). Modulation of gene expression by nutritional state and hormones in Bombyx larvae in relation to its growth period. Gene Expression Patterns (Elsevier Inc.). 25–26: 175–183. IF: 1.154
    15. Kh S. D. and Keshan, B. (2019). Mobilization of fat body glycogen and haemolymph trehalose under nutritional stress in Bombyx mori larvae in relation to their physiological age and the duration of food deprivation. Biologia (Springer). 74: 649–660. IF: 0.728
  2. Publications in Workshop Proceedings/Laboratory Manual
    1. Keshan B. (2011). Molecular aspect of stress endocrinology: cross-talk between signaling molecules and gene expression in fat body and ovary following temperature stress in silkworm, Bombyx mori. Compendium of Progress Report of the Group Monitoring Workshop on DST funded research project under Fast Track Scheme for Young Scientist in Life Sciences, S.No.34.
    2. Chatterjee A. and Keshan B. (2011). Techniques in Molecular Biology. Laboratory Manuals on National Workshop on “Hands-on-Training on Techniques used in Biotechnological Research”, pp.1-18.
    3. Keshan B. (2014). Techniques in Polymerase Chain Reaction. Laboratory Manuals on National Workshop on “Hands-on-Training on Techniques used in Biotechnological Research”, pp.33-44.
  3. Publication in Genbank
    1. Keshan B. and Riddiford L.M. (2004). Manduca sexta E75C (E75C) mRNA, partial cds. GenBank Accession Number AY830446. 17-NOV-2004
    2. Saha N., Biswas K. and Keshan B.  (2008). Clarias batrachus beta-actin mRNA, partial cds. GenBank Accession Number EU527190. 28-Feb-2008
    3. Saha N., Biswas K. and Keshan B. (2008).  Clarias gariepinus beta-actin-like mRNA, partial sequence. GenBank Accession Number EU527191. 28-Feb-2008
    4. Saha N., Biswas K., Jyrwa L.M. and Keshan B. (2008).  Clarias gariepinus phosphoenolpyruvate carboxykinase (PEPCK) mRNA,GenBank Accession Number EU797497. 06-Jun-2008
    5. Saha N., Biswas K., Jyrwa L.M. and Keshan B. (2008). Clarias batrachus phosphoenolpyruvate carboxykinase (PEPCK) mRNA, GenBank Accession Number EU797496. 06-Jun-2008
    6. Saha N., Das K.B., Das M. and Keshan B. (2008).  Heteropneustes fossilis beta-actin mRNA, partial cds. GenBank Accession Number FJ409641. 22-Oct-2008
    7. Saha N., Das M., Biswas Das K. and Keshan B. (2008) Heteropneustes fossilis phosphoenolpyruvate carboxykinase mRNA, partial cds. GenBank Accesssion: FJ594279. 23-Dec-2008
    8. Mihsill K.R.R. and Keshan B. (2019) Pseudonemophas versteegii ecdysone receptor mRNA, partial cds. GenBank Accession: MH580298.1. 10-MAR-2019
    9. Mihsill K.R.R. and Keshan B. (2019) Pseudonemophas versteegii ecdysone-inducible protein E75 mRNA, partial cds. GenBank Accession: MK432951.1. 10-MAR-2019

Papers presented in Conferences/Seminars

  1. Trehalase activity in different fractions of some tissues of silkworm (Bombyx mori L. race Nistari): Demonstration of the highest enzyme activity in mitochondrial compartment. Eightysecond Session of the Indian Science Congress, held in Calcutta (Jadavpur University), India, 1995, January 3-8.
  2. Cellular distribution and estrogen sensitivity of trehalase in silkworm, Bombyx mori L. XIII National Symposium on Reproductive Biology and Comparative Endocrinology, held in Hyderabad (Osmania University), India, under the auspices of 'Society for Reproductive Biology and Comparative Endocrinology (SRBCE)', Chennai, India, 1995, January 27-28.
  3. Action of estradiol-17β on silk gland development and fibroin production in Bombyx mori. Golden Jubilee National Symposium on Biology for Sustainable Development, held in Calcutta (Indian Institute of Chemical Biology), India, 1997, January 16-18.
  4. Possible nuclear mediated and specific action of estradiol-17β in silk gland of Bombyx mori L. XV National Symposium on Reproductive Biology and Comparative Endocrinology, held in Burdwan (The University of Burdwan), India, under the auspices of 'Society for Reproductive Biology and Comparative Endocrinology (SRBCE)', Chennai, India, 1997,  January 23-25.
  5. Possible physiological significance of estradiol –17β in Bombyx mori. National Symposium on Fifty Years of Zoology, held in Calcutta (Indian Science Congress Association). 1999, February 13-14.
  6. Estradiol –17β in silk gland of Bombyx mori. Eightyseventh Session of the Indian Science Congress, held in Pune (University of Pune), India, and presented the paper in the section of Zoology, Entomology and Fisheries under ISCA Young Scientists Programme, 2000, January 3-7.
  7. Developmental expression and hormonal regulation of the transcription factors, E75C and E75D, in Manduca sexta. The 15th International Congress of Comparative Endocrinology, held at Boston, Massachusetts, USA. 2005, May 22-27.
  8. The ecdysone–induced early gene E75 in Manduca sexta: its developmental regulation and hormonal control in epidermis and developing wing. International symposium on Frontiers in Molecular Endocrinology, organized by University of Hyderabad, India, 2005, December 12-15.
  9. Differential regulation of ecdysone-induced early gene E75 by juvenile hormone during molting and metamorphosis in tobacco hornworm, Manduca sexta. The 54th Annual Meeting of the Entomological Society of America (ESA), Indianapolis, USA, 2006, December 10-13.
  10. The alteration in the expression level of ecdysteroid-induced early gene, E75, by juvenile hormone. Regional symposium on current research thrust in animal sciences: Interface with end use researchers and stake holders, Shillong, India, 2007, March 15-16.
  11. Developmental and tissue specific variations in hsp90 and vitellogenin mRNA expressions under heat stress in silkworm, Bombyx mori.18th International Conference (Post ISCBC) prospective and challenges in Chemical and Biological Sciences: Innovative Cross Roads, Institute of Advanced study in Science and Technology (IASST), Guwahati, 2012,  January 28-30.
  12. Heat stress induced response in silkworm, Bombyx mori. 36th Annual Conference of “Ethological Society of India” and National symposium on “Live organisms and their expressions in the environment, University of Calcutta, Kolkata, 2012, November 26-28.
  13. The involvement of ecdysteroid induced early genes, E75A in silkworm, Bombyx mori under heat stress. 100th Session of the Indian Science Congress, University of Calcutta, Kolkata, 2013, January 3-7.
  14. Ecdysone and insulin signaling in insect. International Symposium on Molecular Signaling, Visva-Bharati University, Santiniketan, 2013, February 18-21.
  15. Effect of food deprivation on corpora allata, hemolymph ecdysteroid titer and expression of certain genes in fat body in silkworm, Bombyx mori. National Conference on Applied Zoology in sustainable development: An update, North-Bengal University, 2015, January 30- February 02.
  16. Effect of insulin on hemolymph ecdysteroid titer, glycogen content and expression of certain genes in fed and food deprived larvae in silkworm, Bombyx mori. International symposium on comparative Biology and Comparative Endocrinology, Banaras Hindu University, Varanasi, 2015, February 25-27.
  17. The functional implications of the insulin/insulin signaling pathway in silkworm, Bombyx mori”. 6th Asia Pacific Congress on Sericulture and Insect Biotechnology (APSERI-2019), held at Mysore, India during March 2-4, 2019, organized by the International Sericultural Commission. 

Visiting Fellow

  1. Department of Zoology, University Of Tripura, April 10-17, 2017.

Acted As Reviewer:

  1. Project Review: Department of Biotechnology
  2. Manuscript Review for Scientific Journals:
    • Indian Journal of Experimental Biology
    • General and Comparative Endocrinology (Elsevier Inc)
    • Scientific Reports (Nature Publishing Group)
    • Insect Science (Wiley)
    • Journal of Thermal Biology (Elsevier Inc)

Acted As Resource Person/Invited Talk:

  1. 2005, Invited and presented a paper as state-of-art lecture in “International symposium on Frontiers in Molecular Endocrinology”, organized at University of Hyderabad
  2. 2006, Invited and presented a paper in the Annual Meeting of the Entomological Society of America (ESA) in Indianapolis, USA
  3. 2007, Subject Expert for the television programmes - Educational Multimedia Research Centre, St. Xavier’s College, Kolkata
  4. 2007, Acted as a resource person and delivered two lectures in the Refresher Course in Zoology, UGC-Academic Staff College, North-Eastern Hill University, Shillong
  5. 2008, Acted as a resource person and delivered two lectures in the Refresher Course in Zoology, UGC-Academic Staff College, North-Eastern Hill University, Shillong
  6. 2009, Acted as a resource person and delivered three lectures in the Refresher Course in Zoology, UGC-Academic Staff College, North-Eastern Hill University, Shillong
  7. 2011, Invited and delivered deliver lectures and conducted practical session at National Workshop on “Hands-on Training on Techniques used in Biotechnological Research” at North-Eastern Hill University, Shillong.
  8. 2011, Acted as a resource person and delivered two lectures in the Refresher Course in Zoology, UGC-Academic Staff College, North-Eastern Hill University, Shillong
  9. 2012, Acted as a adjucator for poster presentation for the National Seminar on Faunal Diversity and Ecophysiology, NEHU
  10. 2012, Acted as a resource person and delivered two lectures in the Refresher Course in Zoology, UGC-Academic Staff College, NEHU
  11. 2014, Acted as a resource person and delivered Invited  lectures and conducted practical session at National Workshop on “Hands-on Training on Techniques used in Biotechnological Research” at North-Eastern Hill University, Shillong
  12. 2015, Invited as a Resource Person and delivered lectures and conducted Hands-on training practical session on ‘Molecular Basis of endocrine control of Insect molting and metamorphosis’  at  the 3 days workshop on “Applied Chemical Zoology”, University of Tripura, Tripura.
  13. 2016, Acted as a Co-Chairperson of the Technical Section Biochemical and Molecular basis of Ecophysiology in the Symposium on Faunal Diversity and Ecophysiology, NEHU
  14. 2017, Visiting Fellow to deliver lectures to the M.Sc. students, Department of Zoology, University Of Tripura
  15. 2018, Acted as a Co-Chairperson of two Technical Sessions and adjucator for poster presentation for  “National Conference on Recent Advances in Zoological Research in North East India”, at North-Eastern Hill University, Shillong
  16. 2019, Acted as a resource person and delivered three lectures in the Refresher Course in Zoology, UGC- Human Resource Development Centre, NEHU

Conferences/Symposia/Workshop Organized

  1. Acted as a member of organizing committee for “National Symposium on Advances in Zoology, Faunal diversity and Ecophysiology”, March 2008, Department of Zoology, NEHU, Shillong.
  2. Acted as a member of organizing committee for “20th National Congress of Parasitology”, November 3-5, Department of Zoology, NEHU, Shillong.
  3. Acted as a member of organizing committee for “96th Indian Science Congress”, January 3-7, 2009, NEHU, Shillong.
  4. Acted as Deputy Coordinator for “The National Workshop on “Hands-on Training on Techniques used in Biotechnological Research” organized under “DBT –NER Programme on strengthening of Infrastructure in Biotechnology teaching, training and research”, at NEHU, Shillong, February 28-March, 2011.
  5. Acted as a member of the Sub-Committees for UPE National Symposium (Biosciences) organized by the School of Life sciences, North-Eastern Hill University, Shillong , March 17-19, 2011.
  6. Acted as a member of the organizing committee in lecture series organized by Department of Zoology, NEHU, Shillong under DSA (UGC-SAP) program on March 29, 2011
  7. Acted as a member of organizing committee for “National Seminar on Faunal diversity and Ecophysiology”, February 28-29, 2012, Department of Zoology, NEHU, Shillong.
  8. Acted as a member of organizing committee for “13th International Rotifer Symposium – ROTIFERA XIII”, November 18-24, 2012, Department of Zoology, NEHU, Shillong.
  9. Acted as a member of organizing committee for UPE National Symposium (Biosciences) organized by the School of Life sciences, 2012, March 14-15, North-Eastern Hill University, Shillong , 2012.
  10. Acted as an Executive member (Local Committee) 36th Annual Conference of “Ethological Society of India” and national symposium on “Live organisms and their expressions in the environment, November 26-28, 2012, University of Calcutta, Kolkata.
  11. Acted as a member of organizing committee for The lecture series organized by Department of Zoology, NEHU, Shillong under DSA (UGC-SAP) program, March 20, 2013
  12. Acted as a member of organizing committee and Coordinator from the Department of Zoology for The  National Workshop on “Hands-on Training on Techniques used in Biotechnological Research” under “ DBT-Programme on Improvement of Infrastructure for Biotechnology Teaching, Training & Research in NE India”, organized jointly by Department of Zoology and Department of Biotechnology and Bioinformatics, NEHU, Shillong, February 28 - March 8, 2014
  13. Acted as a member of organizing committee for The Lecture series on “Current Perspective in Zoological Sciences” under the DSA-Phase II (UGC-SAP) Programme, Department of Zoology, NEHU, Shillong, March 28, 2014 
  14. Acted as a member of organizing committee for The Lecture series on “Frontiers in Zoological Sciences” under the DSA-Phase II (UGC-SAP) Programme, at Department of Zoology, NEHU, Shillong, 27th March,  2015
  15. Acted as a member of organizing committee for “Symposium on Faunal Diversity and Ecophysiology” March 30, 2016, Department of Zoology, NEHU, Shillong.
  16. Acted as a member of organizing committee “National Conference on Recent Advances in Zoological Research in North East India”, at North-Eastern Hill University, Shillong held on April 19-20, 2018, Department of Zoology, NEHU, Shillong.

Member of the Academic bodies (NEHU):

  1. Member, Board of Under Graduate Studies, Zoology, NEHU, 2013-15
  2. Member, Board of Post Graduate Studies, Zoology, NEHU, 2013-15.
  3. Member, Board of Studies, Zoology, NEHU, 2014-Present.
  4. Member, School Board, School of Life Sciences, NEHU, 2014-2015, 2018-present.
  5. Member, Academic Council, NEHU, 2018-present
  6. Member, University Court, NEHU, 2018-Present