Prof. R. H. Duncan Lyngdoh

Chemistry Department

Designation: Professor

Present Position   :  Professor (North-Eastern Hill University, Shillong, India)

Post last held        :  Reader (North-Eastern Hill University (Shillong, India)

Educational  Qualifications

  • Ph.D. Indian Institute of Technology Madras, India (1990)
  • M.Sc. (Chemistry) North-Eastern Hill University (1981)                                      

Areas of SpecializationComputational (Theoretical) Chemistry applied to

  1. Organic reaction intermediates: Carbocations, carbenes, nitrenes, arynes
  2. Organic reaction mechanisms: Peroxy oxidations; Pericyclic reactions
  3. Nucleic acids:  DNA, tRNA, H-bonded base pairs; Codon-anticodon pairs
  4. Design of artificial information-bearing macromolecular duplexes
  5. Molecular basis of the Genetic Code and Protein Synthesis (translation)
  6. Chemical Carcinogenesis and Mutagenesis – molecular mechanisms
  7. Metal-Metal Bonds in Transition Metal Complexes

Service Details

  1. Full Professor at Dept of Chemistry, NEHU, since April 2002 till the present
  2. Reader at Dept of Chemistry, NEHU, from November 1998 to March 2002
  3. Lecturer at Dept of Chemistry, NEHU, from September 1993 to October 1998
  4. Lecturer at Institute of Self-Organizing Systems & Biophysics, NEHU, from November 1988 till August 1993
  5. Lecturer at Pachhunga Univetrsity College, Mizoram, from September 1981 to February 1982 (taught B.Sc. Chemistry and Pre-University Science)

Publications:  45 research papers in journals

  1. R. H. Duncan* & G. S. Davies (1989).  Alkylation of DNA Bases by Carcinogenic N-Nitrosamine Metabolities:  A Theoretical Study.  (Int. J. Quantum Chem. 35, 665-671).
  2. R. H. Duncan* & G. S. Davies (1989). Mechanistic Clues to  Mutagenicity of Alkylated DNA Bases: A Theoretical Study.  (J. Theor. Biol. 140, 345-354).
  3. R. H. Duncan* & G. S. Davies (1989).  The Product Distribution of DNA Base Alkylation by N-Nitroso Compounds: An INDO SCF-MO Theoretical Study.  (J. Chem. Soc. Perkin Trans. 2, 2127-2131).
  4. R. H. Duncan (1991).  Acceleration of Self-Consistent Field Convergence in Semi-empirical Molecular Orbital Theory. (Indian J. Chem. 30A, 733-736).
  5. R.H. Duncan Lyngdoh (1992).  Molecular Orbital Elucidations on Repair Mechanisms for Alkylated DNA Nucleosides.  (J. Chem. Soc. Perkin Trans. 2 1173-1179).
  6. R. H. Duncan Lyngdoh (1993). Comparison of Alkyl Group Labilities in O- and N-Alkylated DNA Bases: A Semiempirical Molecular Orbital Study. (Proc. Indian Acad. Sci. Chem. Sci. 105, 253-263).
  7. R. H. Duncan Lyngdoh (1994). Stability of Carcinogenic Nitroso Compounds: A Molecular Orbital Study.  (Indian J. Chem33B, 48-54).
  8. R. H. Duncan Lyngdoh (1994).  Mutagenic Role of Watson-Crick Protons in Alkylated DNA Bases: A Theoretical Study. (J. Biosci. 19, 131-143).
  9. D. Venkateswarlu & R. H. Duncan Lyngdoh* (1995).  Structural, Steric and Energetic Requirements for Induction of Base-Substitutional Mutations by Methylated Guanines and Thymines.  (J. Chem. Soc. Perkin Trans. 2  839-846)
  10. D. Venkateswarlu & R. H. Duncan Lyngdoh* (1995). Proton Transfer Reactions in Nucleic Acid  Bases: A Theoretical Study. (Proc. Indian Acad. Sci. Chem. Sci. 107, 221-231)
  11. J. Sengupta & R. H. Duncan Lyngdoh* (1995). Relative Preference of Carcinogenic Aromatic Nitrenium  Ions for Adduct Formation with Different DNA Base Sites: Theoretical Elucidations.  (J. Biol. Phys21, 285-294)
  12. D. Venkateswarlu & R. H. Duncan Lyngdoh* (1997). Mutagenic Significance of Proton Acidities in Methylated Guanine and Thymine Bases and Deoxynucleosides : A Theoretical Study. (J. Molec. Struct. THEOCHEM  393, 151-161)
  13. D. Venkateswarlu, R. H. Duncan Lyngdoh & M. Bansal (1997). A Semiempirical SCF-MO Study on the Base-Pairing Properties of 8-Oxopurines: Significance for Mutagenicity(J. Chem. Soc. Perkin Trans. 2, 621-626)
  14. J. Sengupta & R. H. Duncan Lyngdoh* (1997). Comparison of the Relative Physicochemical Role of Parent, Proximate, and Ultimate Carcinogenic Forms of Aromatic Amines: A Semiempirical Molecular Orbital Study. (J. Indian Chem. Soc. 74, 119-122) 
  15. D. Venkateswarlu & R. H. Duncan Lyngdoh* (1998). Deglycosylation of DNA Nucleosides with Relevance to Repair and Mutagenic Mechanisms: A Theoretical Study.(J. Molec. Struct. THEOCHEM  418, 49-58)
  16. J. Sengupta & R. H. Duncan Lyngdoh (1998). Theoretical Study on Tautomeric Role of Modified Guanines for Aromatic Amine Carcinogenesis.  In “Sustainable Development and Environment”, Vol. 2 chapter 39; eds..A K De, A K Mitra, N C Dutta and T R Sinha (Vedams Books, New Delhi)
  17. Deborah L. Buam & R. H. Duncan Lyngdoh* (2000).  Self-Associative Base-Pairing in some Nitrogen Heterocycles: A PM3 SCF-MO Study. (J. Mol. Struct. THEOCHEM  505, 149-159)
  18. Peter G.S. Dkhar and R. H. Duncan Lyngdoh* (2000).  Generation, Structure and Reactivity of Arynes: A Theoretical Study. (Proc. Indian Acad. Sci. Chem. Sci. 112,  97-108)
  19. P. Munindro Singh & R. H. Duncan Lyngdoh* (2001). Symmetrical Transition States in Thermoneutral Reactions: A Semi-empirical Molecular Orbital Study. (Indian J. Chem. 40A, 682-686)
  20. S. Ulen Mangang & R. H. Duncan Lyngdoh* (2001). Wobble Base-Pairing in Codon-Anticodon Interactions: A Theoretical Modelling Study. (Indian J. Biochem. Biophys. 38, 115-119)
  21. Deborah L. Buam & R. H. Duncan Lyngdoh* (2002). Information-bearing Base-pair Sets involving Nitrogenous Heterocycles: A Theoretical Modelling Study. (Indian J. Chem. 41B, 2346-2356)
  22. Pebam Munindro Singh & R. H. Duncan Lyngdoh* (2004).  Theoretical Perspectives on the Cope Rearrangement in Bullvalene Systems. (Indian J. Chem. 43, 1958-1968)
  23. Zodinpuia Pachuau & R. H. Duncan Lyngdoh* (2004).  Molecular Orbital Studies on the Wagner-Meerwein Rearrangement in some Acyclic Pinacol-Pinacolone Rearrangements. (J. Chem. Sci. 116, 83-91)
  24. Peter G. S. Dkhar & R. H. Duncan Lyngdoh* (2005). Transition States for Hydride and Methyl 1,2-Migrations in Carbene Rearrangements to Alkenes : An AM1 SCF-MO Study. (Indian J. Chem. 44B, 2138-2148)
  25. Peter G. S. Dkhar & R. H. Duncan Lyngdoh* (2006).  Ring Expansions in Substituted Phenylnitrenes : An AM1 SCF-MO Study  (J. Mol. Struct. THEOCHEM 732, 161-171)
  26. Siamkhanthang Neihsial and R. H. Duncan Lyngdoh* (2007).  Novel H-bonded Base Pairs as Potential Repeat Units for Information-Bearing Macromolecular Duplexes: A B3LYP/6-31G* Search  (J. Mol. Struct. THEOCHEM 806, 213-221.)
  27. Gunajyoti Das & R. H. Duncan Lyngdoh* (2008).  Can Configuration of Solitary Wobble Base Pairs Determine Specificity and Degeneracy of the Genetic Code? Clues from Molecular Orbital Modeling Studies. (J. Mol. Struct. THEOCHEM 851, 319-334)
  28. Siamkhanthang Neihsial & R. H. Duncan Lyngdoh* (2008). Novel H-bonded Base Dimers as Repeat Units for Information-bearing Self-Associative Duplexes: A B3LYP-6-31G* Search. (J. Comput. Chem. 29, 1788-1797)
  29. A. Munaf Kharbuli & R. H. Duncan Lyngdoh* (2008). Ozonolysis of Methyl, Amino and Nitro Substituted Ethenes: A Semi-empirical Molecular Orbital Study. (J. Mol. Struct. THEOCHEM 860, 150-160).
  30. R. H. Duncan Lyngdoh & Henry F. Schaefer, III* (2009). Elementary Lesions in DNA: Electron, Proton, Hydrogen Atom and Hydride Transfers. (Acc. Chem. Res. 42, 563-572) 
  31. Henry N. Pangamte & R. H. Duncan Lyngdoh* (2010). Stability, Singlet-Triplet Splitting and  Structure of Didehydrogenated Quinolynes and Isoquinolynes. (J. Phys. Chem. A 114, 2710-2726)
  32. Gunajyoti Das & R. H. Duncan Lyngdoh* (2012). Role of wobble base pair geometry for   codon degeneracy: Purine-type bases at the anticodon wobble position. (J. Mol. Model. 18, 3505-3820)
  33. Z. Pachuau, Kiew S. Kharnaior & R. H. Duncan Lyngdoh* (2013). Isomerization of Propargyl Cation to Cyclopropenyl Cation:  Mechanistic Elucidations and Effects of Lone Pair Donors. (J. Chem. Sci. 125, 365-378)
  34. Gunajyoti Das & R. H. Duncan Lyngdoh* (2013). Configuration of Wobble Base Pairs having Pyrimidines as Anticodon Wobble Bases: Significance for Codon Degeneracy. (J. Biomol. Struct. Dynam. 32, 1500-1520)
  35. Kiew S. Kharnaior & R. H. Duncan Lyngdoh* (2014).  Exploration of Minima on the C7H7+ Surface: Structural, Stability and Charge-related Considerations. (J. Chem. Sci. 126, 1181-1195)
  36. Shilpi Mandal, R. H. Duncan Lyngdoh, Hassan Askari & Gunajyoti Das* (2015). Metalation of Glycylglycine: An Experimental Study Performed in Tandem with Theoretical Calculations. (J. Chem. Engg. Data 60, 659-673) 
  37. S. Premila Devi, Tejeswori Salam, R. H. Duncan Lyngdoh* (2016). Uncatalyzed Thermal Gas Phase Aziridination of Alkenes by Organic Azides. Part I: Mechanisms with Discrete Nitrene Species. (J. Chem. Sci. 128, 681-693)
  38. K. S. Kharnaior, Martina Devi and R. H. Duncan Lyngdoh* (2016). Generation of C7H7+ Cations with Isomerization Reactions. (Comput. Theor. Chem. 1091, 150-164)
  39. Martina Devi and R. H. Duncan Lyngdoh* (2016). Favored and Less Favored Codon-Anticodon Duplexes Arising from the GC Codon Family Box encoding for Alanine: Some Computational Perspectives. (J. Biomol. Struct. Dynam. 36, 1-21)
  40. Tejeswori Salam, S. Premila Devi & R. H. Duncan Lyngdoh* (2017). Molecular Criteria for Mutagenesis by DNA Methylation: Some Computational Elucidations. (Mutat. Res. 807, 10-20)
  41. K. S. Kharnaior, R. H. Duncan Lyngdoh* & A. K. Chandra* (2017). C4H4 Radical Cation Isomers: Generation, Structure, Stability, and Isomerization Reactions. (Comput. Theor. Chem. 1115, 158-168)4
  42. Martina Devi, Esther Chingbiaknem & R. H. Duncan Lyngdoh* (2018). A Molecular Mechanics Study on GA Codon Box Translation. (J. Theor. Biol. 441, 28-43)
  43. Esther Chingbiaknem, S. Neihsial & R. H. Duncan Lyngdoh* (2018). Isomorphic Repeat Units for Putative Information-bearing H-bonded Duplexes. Part I. Pyrimidine Base Pairs with Polyamide Backbone. (Comput. Theor. Chem. 1126, 33-43)
  44. R. H. Duncan Lyngdoh*, R. Bruce King* & Henry F. Schaefer* (2018). Metal-Metal Bond Distances and Bond Orders in Binuclear Metal Complexes of the First Row Transition Metals Titanium through Zinc. (Chem. Rev. 118, 11706-11787).
  45. S. Premila Devi & R. H. Duncan Lyngdoh* (2019). Uncatalyzed Thermal Gas Phase Aziridination of Alkenes by Organic Azides. Part 2: Whole Azide Reaction with Alkene. (J. Chem. Sci. 131, 6).

Research Guidance for Ph.D. (List of PhD students successfully guided)

1 Dr. D. Venkateswarlu Theoretical Studies on Alkylated DNA Bases and their  Role for Mutagenesis and Carcinogenesis       1995
2 Dr. Jayati Sengupta Theoretical Investigations on the Role of Modified DNA for Carcinogenesis by Polycyclic Aromatic Amines    1996
3 Dr. James Haorah Mechanistic Models for Carcinogenic Activity, Potency Index and Choice of Target Organ for Carcinogenesis by N-Nitroso Compounds 1997
4 Dr. Deborah M. L. Buam Quantum Chemical Studies on the Salient Aspects of Hydrogen Bonding Among Aromatic Heterocyclic Bases 2000
5 Dr. Peter G. S. Dkhar Theoretical Aspects of the Generation, Structure. Stability and Reactivity of Carbenes, Nitrenes and Arynes 2004
6 Dr. P. Munindro Singh Theoretical Aspects of Intramolecular Diels-Alder React-ions. Sigmatropic Shifts & Degenerate Cope Rearrangements 2005
7 Dr. Zodinpuia Pachuau Theoretical Studies on Carbocations:  Stability, Structure and Rearrangements 2006
8 Dr. Siam K. T. Neihsial Quantum Chemical Studies on H-Bonded Base Pair and Backbone Components of Novel Information-Bearing Macromolecular Duplexes 2010
9 Dr. A. Munaf Kharbuli Quantum Chemical Studies on the Oxidation of Alkene and Carbonyl Substrates by Ozone, Peracids and Peroxides 2012
10 Dr. Gunajyoti Das Theoretical Investigations on Codon-Anticodon Inter- actions and their Significance for the Genetic Code 2012
11 Dr. Kiew S. Kharnaior Quantum Chemical Studies on the Structure, Stability and Rearrangements of Various CnHn+ Carbocations (n=4 to 7) 2013
12 Dr. Henry N. Pangamte Quantum Chemical Investigations on Arynes: Quinolynes and Isoquinolynes 2013
13 Dr. Tejeshwori Salam  Base Pairing Motifs and Repair Mechanisms Associated Alkylated DNA: Some Computational Insights 2015
14 Dr. S. Premila Devi Computational Studies on Metal-Free and Metal-Catalysed Nitrene Transfer Reactions 2016
15 Dr. Sanchita Dhar*  Synthetic and Mechanistic Investigations on α-Oxoketene Dithioacetals 1999
16 Dr. Amrita Roy*  Synthetic Investigation on Aromatic and Heteroaromatic Annelation Reactions 1999
17   Dr. Okram Barun*  New Synthetic Routes to Biologically Important Heterocycles 2000

* With Joint Supervision of Professor H. Junjappa (Emeritus Professor, IIT Kanpur)

Ph.D. Students Registered and under Current Supervision

01 Ms. Martina Devi  Computational Investigations on the Molecular Basis of the Genetic Code  2012 (regn.)
02 Ms. Esther Chingbiaknem Computational Studies on Hydrogen-Bonded Macromolecular Duplexes- 2012 (regn.)
03 Mr. Fitzerald Hujon Binuclear and Polynuclear Complexes of Manganese, Iron And Cobalt: Computational Studies on Structure and Stability  2016
04 Mr. Derek R. Langstieh Metal-Metal Bonds in Binuclear Complexes of Vanadium and Nickel: Some Computational Perspectives 2017
05   Ms. Ibaniewkor Lyngdoh*  Synthesis and Characterisation of Platinum Group Metal Scorpionates with N-donor Ligands 2010 (subm.)

* With Dr. E. K. Rymmai (Dept of Chemistry, NEHU) as Supervisor and Self as Joint Supervisor

Note: All above 17 completed Ph.D. degrees were awarded by North-Eastern Hill University and all 22 research scholars were registered for the Ph.D. programme of NEHU

Research Projects as Principal Investigator

  1. BRNS DAE Project on “Theoretical Studies on the Somatic Mutation Model of  Cancer” (1990-1993) with one Research Fellow (JRF and SRF)
  2. SERC DST Project on “Theoretical Studies on Codon-Anticodon Pairing and the Genetic Code” with one Research Fellow (1994-1997)
  3. HRDG CSIR Project on “Computational Elucidations on Codon-Anticodon Pairing and the Genetic Code” with one Research Associate (2011-2013)

Organization of Conferences/Symposia:

  • Convener, Chairman and Organizing Secretary for 14th Annual Conference of the Indian Association for Cancer Research entitled “Cancer Research: Bridging the Gap between Laboratory and Clinic” (North-Eastern Hill University, Shillong, Feb 1994).
  • Convener & Organizing Secretary for the National Symposium on Advances in Chemistry & Environmental Impact (North-Eastern Hill University, March 2006).    
  • Convener & Organizing Secretary for National Symposium on “Sustainable Chemistry: Frontiers & Challenges” held at NEHU 27th Feb to 1st March 2014.

Presentations at Conferences/Symposia etc.

      Have given Invited Lectures/Oral Presentations at many National and International Symposia/Conferences, besides Workshops and Refresher Courses, and delivered three Keynote Addresses at National Seminars/Conferences.

Administrative Experience

  1. Head, Department of Chemistry, NEHU, Shillong (Feb 2006 to Feb 2009)
  2. Coordinator, DST FIST Program, Dept of Chemistry, NEHU (2006-2009)
    Prepared/presented Proposal which resulted in FIST Level Two (Rs 168 lakhs)
  3. Coordinator, UGC-SAP Program, Dept of Chemistry, NEHU (2011 till present)
    Prepared/presented Proposal leading to Centre of Advanced Study (Rs 1.50 crore)
  4. Dean, School of Physical Sciences, NEHU (Feb 2017 till present)
  5. Member of numerous Administrative Committees of NEHU and other institutions.

Educational Tours

Organized and led the M.Sc. students of the Dept of Chemistry, NEHU, on a series of six educational tours around India in 1998, 1999, 2001, 2005, 2009 and 2014.

Foreign Collaborations

  1. With Professor Henry F. Schaefer, III of University of Georgia, Athens, USA
  2. With Professor Feng Wang of Swinburne University, Melbourne, Australia

Other Interests

  1. Music – composed 32 full vocal and instrumental works; play piano, organ, guitar; sing; conduct choirs, perform piano in classical music concerts
  2. Languages – read, speak and write English and 9 Indian languages; specialized in study of Tibeto-Burman languages (especially the Meitei-Chin group)
  3. Theology and philosophy of religion
  4. Indigenous Tribal Folklore – engaged in translation of ancient Mizo folktales
  5. Appreciation & History of Art – painting, sculpture and architecture
  6. History and culture of North-East India