R. L Nongkhlaw

Prof. R. L Nongkhlaw

0364 2307930 - 2628

0364 2307930 - 6628(R)

9436101349

rlnongkhlaw@nehu.ac.in

Faculty members

Prof. R. L Nongkhlaw

Designation: Professor

Department: Chemistry

Qualifications:

M.Sc (NEHU), Ph.D (NEHU)

Areas of Interest/Specialization: 

Organic Chemistry

Research Interest:

  • Synthesis of pharmacologically important Heterocycles: Synthetic approaches to Oxygen, Nitrogen and Sulphur Heterocycles via green protocols and studies on their biological properties.
  • Synthesis of Nanoparticles and organo-nanocatalysts: Preparation of metal (ferromagnetic as well as non-ferromagnetic) nanoparticles via chemical methods, and investigation on its catalytic properties in organic synthesis. Development of coated/ hybrid organo-nanocatalyst for advanced synthesis

Experience: 20 Years 

PhD Awarded/Supervised: 

  • Awarded: 14
    1. Dr. George Kupar Kharmawlong
    2. Dr. Noimur Rahman
    3. Dr. Ridaphun Nongrum
    4. Dr. Jims World Star Rani
    5. Dr. Geetmani Singh Nongthombam
    6. Dr. Chingrishon Kathing
    7. Dr. ShokipTumtin
    8. Dr. Satyapati Devi
    9. Dr. Tovishe Phucho
    10. Dr. Madhushudhan Saha
    11. Dr. Milan Chandra Dutta
    12. Dr. Arup Dutta     
    13.  Dr. Kmendashisha Wanniang
    14.  Dr. Ibakyntiew D. Marpna     
  • Result Awaited: 2
    • Mr. Tyrchain M. Lipon
    • Mr. Aiborlang Thongni
    Ongoing: 5
    • Ms Munmee Goswami
    • Ms Pooja Paul
    • Ms Ridahunlang Nongkhlaw
    • Ms Mebalari Thangkhiew
    • Mr Nicky Jones Lyngdoh Marshillong
    • Ms Naphisabet Nongkhlaw

       MSc. Project Students Supervised: 42

Administrative responsibilities undertaken:

  1. Dean, Students’ Welfare (Shillong Campus), NEHU:  March 2021-onwards.
  2. Warden, Ranggira Hostel, Hostel No 19: From August 2008 till September 2015.
  3. University Proctor (Shillong Campus), NEHU: 2015- Feb, 2021.
  4. Convener of the Anti-Ragging Committee.
  5. Convener of the Anti-Ragging Squad.
  6. Member of Election Commission of NEHUSU.
  7. Member of the University Level Disciplinary Council.
  8. Member of the Residential Allotment Committee for Hostel allotment.
  9. Member of the Students Counselling Cell.
  10. Member of the Committee for University Memorabilia.
  11. Chairman of “The Chemistry Club, Department of Chemistry” from 2012 onwards.
  12. Nodal Officer for the Awareness programmes on Drug abuse and prevention in Colleges and central Universities.

Academic affiliations :

  1. Life member of The Indian Science Congress Association, Kolkata
  2. Life member of the Indian Council of Chemists
  3. Life member of The Chemical Research Society of India
  4. Member, Board of Under Graduate Studies in Chemistry, NEHU
  5. Member, Board of Post Graduate Studies in Chemistry, NEHU
  6. Member, Board of Post Graduate Studies in Biochemistry, NEHU
  7. Member, School Board of Physical Sciences, NEHU
  8. Member, Board of Studies in Chemistry, NEHU
  9. Member, Admission Committee for PhD and MSc.
  10. Member, Meghalaya Medical Entrance Test (MMET)

Research Projects

  • Department of Science and Technology- Science and Engineering Research Board (DST-SERB) sponsored project entitled "Synthetic studies on organo encapsulated nanoparticles for fabrication of C-N, C-O, C-S bonds leading to 5- and 6-membered rings."(Completed)
  • Department of Science and Technology- Science and Engineering Research Board (DST-SERB)) sponsored project entitled "An approach towards asymmetric synthesis via the C-H bond activation assisted by chiral organo- metallic species as catalytic system." (Ongoing)
  • Indian Council of Medical Research (ICMR) sponsored project entitled "To study the inhibition of angiopietin like protein-4 (Angptl-4) secretion, A potential target of atherosclerotic- cardiovascular disease by ursolic acid         and    Its synthetic derivatives." (Ongoing)

Publications

Selected Publications:

  1. Munmee Goswami, Pooja Paul, Chayan Pandya, Ridahunlang Nongkhlaw, Arup Dutta, Jyothi Kumari, Dharmarajan Sriram, Akella Sivaramakrishna, Rishanlang Nongkhlaw*, Photo Catalytic Activity of Rose Bengal Encapsulated on Zeolitic Imidazolate Framework-8 (RB@ZIF-8): An Innovative Approach for the One Pot Synthesis of Highly Functionalized Tetrahydropyridines and Study of their Anti-tubercular Activity. Catal. Sci. Technol., 2024, DOI: 10.1039/D4CY00218K
  2. A. Thongni, R. Nongkhlaw, C. Pandya, A. Sivaramakrishna, P.M. Gannon, W. Kaminsky, Microwaveâ?assisted synthesis of benzo[4,5]imidazo[1,2â?a]pyrimidines and pyrano[4,3â?b]pyrans catalyzed by Lâ?glutamine functionalized magnetic nanoparticles in water:ethanol mixture, Journal of Heterocyclic  Chemistry,  2024, 1–19.
  3. K. Wanniang, T.M. Lipon, I.D. Marpna, O.R. Shangpliang, B. Myrboh, R. L. Nongkhlaw, Oxidative α-sulfonyloxylation of aryl ketones with sulfonic acids by lead tetraacetate, Indian Journal of  Chemistry, 2023, 62, 1103–1107.
  4. R. Nongrum, R. Nongkhlaw, S.P. Majaw, J. Kumari, D. Sriram, R. Nongkhlaw, A nano-organo catalyst mediated approach towards the green synthesis of 3-methyl-4-(phenyl)methylene-isoxazole-5(4H)-one derivatives and biological evaluation of the derivatives as a potent anti-fungal and anti-tubercular agent, Sustainable Chemistry & Pharmacy, 2023, 32, 100967.
  5. J. World, S. Rani, G. Sing, C. Kathing, R. Nongrum, G. Kharmawlong K., R. Nongkhlaw, Fe3O4 supported acidic ionic liquid: An efficient and recyclable magnetic nanoparticles catalyst for one-pot synthesis of Bis(indolyl)methanes, Indian Journal of  Chemistry, 2023,  62, 16–23.
  6. R. Nongkhlaw, R. Bisht, R. Nongkhlaw, Isoniazid Derivatives as Anti-Tubercular Agents: From Structural Design to Clinical Investigations, Infectious Disorders - Drug Targets, 2023, 23, e041022209552.
  7. G. Kumar, A. Dutta, M. Goswami, B. Meena, S. Parasuboyina, R. Nongkhlaw, D.T. Masram, Synthesis of Zr-MOF/rGO-nanocomposites used for spirooxindole scaffolds derivatives, Journal of Molecular Structure, 2023, 1287, 135653.
  8. A. Thongni, P.T. Phanrang, C. Pandya, D.F. Diengdoh, P.M. Gannon, W. Kaminsky, R. Nongkhlaw, J. Kumari, D. Sriram, A. Sivaramakrishna, R. Nongkhlaw, Ultrasound assisted synthesis of spirooxindole analogs catalyzed by Fe3O4@PPCA NPs: Experimental, theoretical and in vitro biological studies, Journal of Molecular Structure, 2023, 1284, e135363.
  9. A. Dutta, M. Goswami, J. Rabha, S. Das,  D. K. Jha and R. Nongkhlaw; Fe3O4@RB@LDH: Efficient and recyclable photocatalyst visible-light mediated synthesis of pyran and pyrrolidinone derivatives and their anti-microbial activities, Chemistry Select, 2022, 7, 1-13.
  10. A. Thongni, P. T. Phanrang, A. Dutta and R. Nongkhlaw; One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol, Synthetic Communications,  2021, 1-21.
  11. T. M. Lipon, I. D. Marpna, K. Wanniang, O. R. Shangpliang, B. M. Laloo, R. Nongkhlaw and B. Myrboh; Selenium dioxide-mediated bromination of α,β-unsaturated ketones using n-bromosuccinimide in the presence of p-toluenesulfonic acid: a versatile route for the synthesis of α′-bromo-4-arylbut-3-en-2-one and α′,α′-dibromo-4-arylbut-3-en-2-one, ACS Omega, 2021, 6, 41, 27466-27477.
  12.   A. Dutta, S. K. Patra, S. Khatua and R. Nongkhlaw; Visible-light-mediated synthesis of 3, 4, 5-trisubstituted furan-2-one derivatives via a bifunctional organo photocatalyst, New Journal of Chemistry, 2021, 45, 19329-19337
  13. M. Goswami, A. Dutta, P. Paul and R. Nongkhlaw, Recent developments on catalyst-free, visible-light-triggered synthesis of heterocyclic scaffolds and their mechanistic study, Chemistry Select, 2021, 6, 9684-9700.
  14. A. Dutta, M. A. Rohman, R. Nongrum, A. Thongni, S. Mitra and R. Nongkhlaw; visible-light-promoted synthesis of pyrrolidinone derivatives via rose bengal as a photoredox catalyst and their photophysical studies, New Journal of Chemistry, 2021, 45, 8136–8148.
  15. A. Dutta, N. Rahman, J. E. Kumar, J. Rabha, T. Phukan and R. Nongkhlaw; Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities, Synthetic Communications, 51, 2021. https://doi.org/10.1080/00397911.2020.1825741
  16. C. Kathing, N. G. Singh, J. World Star Rani, R. Nongrum, and R. Nongkhlaw; facile synthesis of 1,2-disubstituted benzimidazoles using p-toluenesulfonic acid through grinding method; Russian Journal of Organic Chemistry, 2020, 56, 1628–1634, DOI: 10.1134/S1070428020090201
  17. A. Dutta, B. Chhetri, R. Nongrum, G. K. Kharmawlong, A. K. Yadav and R. Nongkhlaw; Ultrasound-assisted synthesis of nitrogen and oxygen containing heterocycles using fluorinated graphene oxide as catalyst: evaluation of their anthelmintic activities, Chemistry Select, 2020, 5, 7474-7481.
  18. A. Dutta, N. Rahman, W. Khongriah, R. Nongrum, S. R. Joshi and R. Nongkhlaw; L-glutamine supported on core–shell silica iron oxide nanoparticles: a highly efficient organocatalyst for synthesis of spirooxoindoles, Chemistry Select, 2019, 4, 12399-12408.
  19. R. Nongrum, G. Kharmawlong, J. W. S. Rani, N. Rahman, A. Dutta and R. Nongkhlaw; Organocatalytic green approach towards the fabrication of fused benzo N,N-containing heterocycles facilitated by ultrasonic irradiation, Journal of Heterocyclic Chemistry, 2019, DOI:10.1002/jhet.3680.
  20. G. K. Kharmawlong, R. Nongrum, B. Chhetri, J.W. S. Rani, N. Rahman, A. K. Yadav and R. Nongkhlaw; Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies, Synthetic Communications, 2019, 49, 2683-2695. doi.org/10.1080/00397911.2019.1639754.
  21. R. Nongrum, G. S. Nongthombam, J. W. S. Rani, N. Rahman, G. Kharmawlong and R. Nongkhlaw; [1,3-Oxazines: green synthesis by sonication using a magnetically-separable basic nano-catalyst and investigation of its biological activity, Environmental Chemistry Letters, 2019, 17, 1325-1331.
  22. R. Nongkhlaw, R. Nongrum, S. Tumtin and I. T. Phucho; Green and efficient synthesis of 1,2-bis(2H-benzo[e][1,3]oxazin-3(4H)-yl)ethanes and 1,2-bis (2H-benzo[e][1,3]thiazin-3(4H)-yl)ethanes; Arkivoc, 2019, 5, 255 264.
  23. N. Rahman and R. Nongkhlaw, Recent advances in organo-nanocatalysis in the field of green organic synthesis, Arkivoc, 2018, 6 272-313. 
  24. N. Rahman, G. S. Nongthombam, J. W. S. Rani, R. Nongrum, G. K. Kharmawlong and R. Nongkhlaw; An environment-friendly magnetic organo-nanomaterial as a potent catalyst in synthesis of pyranopyrazole derivatives. Current Organocatalysis, 2018, 5(2), 150-161.
  25. N. G. Singh, G. K. Kharmawlong, J. E. Kumar and R. Nongkhlaw; UV-365 light promoted catalyst-free synthesis of pyrimido[4,5-b] quinoline-2,4-diones in aqueous-glycerol medium. New Journal of Chemistry, 2018, 42, 9436- 9442.
  26. N. G. Singh and R. Nongkhlaw; Experimental and theoretical studies on SPION@glutathione catalyzed synthesis of indolylchromene, indolo xanthene and pyrimido[4,5 b]quinoline. Synthetic Communications, 2018, 48(5), 541- 552.
  27. R. Nongrum, G. S. Nongthombam, M. Kharkongor, J. W. S. Rani, N.  Rahman, C. Kathing, B. Myrboh and R. Nongkhlaw; A Nano-organocatalyzed route towards the efficient synthesis of benzo[b]pyran derivatives under Ultrasonic irradiation. RSC Adv., 2016, 6, 108384-108392.
  28. J.W.S. Rani, C. Kathing, N. G. Singh, R. Nongrum, N. Rahman, G. Kharmawlong, R. Nongkhlaw; One-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones catalysed by [BMIM]Br under solvent-free condition. Bulgarian Chemical Communications, 2016, 48(4), 3-10.
  29. C. Kathing, S. Kumar, S. Tumtin, N. G. Singh, Jims W. S. Rani, R. Nongrum, and R. Nongkhlaw; N,N′-Dialkyl-4-Aryl-3,4-Dihydropyrimidinones and Thiones: Ceric Ammonium Nitrate Catalyzed Synthesis and Molecular Structure Determination by X-ray Crystallography. Journal of Heterocyclic Chemistry, 2016, 54(2), 2735-2738.
  30. N. G. Singh, M. Lily, S. P. Devi, N. Rahman, A. Ahmed, A. K. Chandra and R. Nongkhlaw; Synthetic, mechanistic and kinetic studies on the organo-nanocatalyzed synthesis of oxygen and nitrogen containing spiro compounds under ultrasonic conditions.  Green Chemistry, 2016, 18, 4216-4227.
  31. N. G. Singh, R. Nagarajaprakash, J. W. S. Rani, C. Kathing, R. Nongrum and R. Nongkhlaw; Nickel nanoparticles assisted regioselective synthesis of pyrazoloquinolinone and triazolo-quinazolinone derivatives. New Journal of Chemistry, 2015, 39, 3908-3915.
  32. S. Tumtin, C. Kathing, I. T, Phucho, R. Nongrum, B. Myrboh and R. Nongkhlaw; Triethylbenzylammonium chloride as a useful and efficient catalyst for the alkylation of Indole/substituted Indoles in Water: A Comparative Study between Conventional-and Microwave Irradiation. J. Chin. Chem. Soc., 2015, 62(4), 321–327.
  33. C. Kathing, Jims W. S. Rani, Nongthombam G. Singh, S. Tumtin, R. Nongrum and R. Nongkhlaw; One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones catalyzed by cupric acetate under solvent-free conditions. J. Chin. Chem. Soc., 2014, 61, 1254-1258.
  34. N. G. Singh, R. Nongrum, C. Kathing, J. W. S. Rani and R. Nongkhlaw; Bakers' yeast: An environment benign catalyst for the one-pot synthesis of Indolylchromenes and Bisindolylalkanes. Green Chem. Lett. & Rev., 2014, 7, 137-144.
  35. N. G. Singh, C. Kathing, J. W. S. Rani and R. Nongkhlaw; An efficient and versatile protocol for the synthesis of bis(indolyl)alkanes and tris(indolyl)alkanes using chlorotrimethylsilane. J. Chin. Chem. Soc., 2014, 61, 442-446.
  36. C. Kathing, S. Tumtin, N. G. Singh, J. W. Rani, I. T. Phucho, A. Nongpiur, R. Nongrum and R. L. Nongkhlaw; Cupric acetate catalysed alkylation of indoles in water: A comparative study between conventional heating and microwave irradiation. Organic Chemistry An Indian Journal, 2013, 9, 257- 266.
  37. A. S. Devi, P. Helissey, R. Nongkhlaw and J. N. Vishwakarma; KHSO4-assisted Michael addition-Elimination reactions of Indoles dimethyl amino-1-phenylprop-2-en-1-ones in water: An Environment friendly synthesis of Novel 3-indolylchalcone.Synth.Commun., 2013, 43, 1653- 1660.
  38. B. M Laloo, H. Mecadon, Md. R. Rohman, I. Kharbangar, I. Kharkongor, M. Rajbangshi, R, Nongkhlaw and B. Myrboh. Reaction of Selenium Dioxide with Aromatic Ketones in the Presence of Boron triflourideEtherate: A protocol for the Synthesis of Triarylethanones. J. Org. Chem., 2012, 77, 707- 712.
  39. I. T. Phucho, S. Tumtin, A. Nongpiur, R. Nongrum, C. Kathing and R. Nongkhlaw. Microwave assisted synthesis of 3-substituted-4(3H)-quinazolinone using silica supported potassium carbonate. Organic Chemistry an Indian Journal; 2012, 8, 145 – 150.
  40. M. Saha, E. Karim, J. N. Vishwakarma and R. Nongkhlaw. Microwave Assisted One-pot Synthesis of Novel bioactive 1-Phenylethylhexahydroquinazolin-5(6H)-ones & bis-1-Phenylethylhexahydroquinazolin-5(6H)-ones. Chemical Sciences Journal, 2012, 89, 117- 120.
  41. S. Tumtin, T. Phucho, A. Nongpiur, R. Nongrum and R. Nongkhlaw; One pot synthesis of [1,3]-oxazine and [1,3]-thiazine derivatives under thermal and microwave conditions. Journal of Heterocyclic Chemistry, 2010, 47, 125-130.
  42. I. T. Phucho, S. Tumtin, A. Nongpiur, R. Nongrum and R. Nongkhlaw; Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl-2-oxo-4-arylpyrimidine-5-carboxamide and 3,4-dihydropyrimidin-2(1H)-ones under solvent free conditions. Journal of Chemical and Pharmaceutical Research, 2010, 2(3), 214-222.
  43. A. S. Devi, M. C. Dutta, R. Nongkhlaw and J. N. Vishwakarma. KHSO4 assisted Michael addition-elimination reactions of formylatedacetophenones in water: a facile general green synthetic route to 3-(alkyl/aralkyl/aryl) amino-1-arylprop-2-en-1-ones. Journal of the Indian Chemical Society, 2010, 87(6), 739-742.  
  44. M. C. Dutta, K. Chanda, R. Nongkhlaw and J. N.Vishwakarma, A facile microwave-assisted one-pot strategy for the synthesis of bis-hexahydroquinazolin-5(6H)-ones. E-Journal of Chemistry, 2010, 7(1), 281-286.
  45. J. N. Vishwakarma, M. C. Dutta, K. Chanda, B. Das, M. A. Laskar and R. Nongkhlaw, Synthesis and anti-bacterial activities of novel 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines and bis(5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines), ARKIVOC (Gainesville, FL, United States) 2009, (13), 131-141.
  46. I. T. Phucho; A. Nongpiur.; S. Tumtin, R. Nongrum, R. Nongkhlaw; Recent progress in the chemistry of dihydropyrimidinones; Rasayan Journal of Chemistry (2009), 2(3), 662-676. 
  47. I. T Phucho, S. Tumtin, A. Nongpiur, R. Nongrum, C. Kathing, R. Nongkhlaw; Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl-2-oxo-4-arylpyrimidine-5-carboxamide and 3,4-dihydropyrimidin-2(1H)-ones under solvent free conditions; Journal of Chemical and Pharmaceutical Research, 2010, 2(3), 214-222
  48. I. T Phucho, S. Tumtin, A. Nongpiur, R. Nongrum, C. Kathing, R. Nongkhlaw; Synthesis of 3,4-dihydro-2(1H)-pyrimidinone and 3,4,5,6,7,8-hexahydro-2(1H)-quinazolinones via three component  cyclocondensation; Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2010,  49B(3), 346-350
  49. I. T.  Phucho, A. Nongpiur, S. Tumtin, R. Nongrum, B. Myrboh and R. Nongkhlaw, Novel one pot synthesis of substituted 1,2,4-triazines. ARKIVOC (Gainesville, FL, United States) 2008, (15), 79-87.
  50. R. Nongkhlawand B. Myrboh, Novel one-pot synthesis of substituted 1,2,4-triazines. Heterocyclic Communications, 2006, 12(1), 67-72.  
  51. R. Nongkhlaw, R. Nongrum, I. Nongkynrih, F. Mathew and B. Myrboh, Novel synthesis of substituted cyclopropane acetic acid ethyl esters from cyclopropyl alkyl ketones. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2005, 44B (5), 1054-1057.
  52. R. Nongkhlaw, R. Nongrum, and B. Myrboh, A novel one-pot synthesis of substituted pyridazines: A general method of preparation of 3,4,6-triarylpyridazines, Heterocyclic Communications, 2003, 9(5), 465-472.
  53. R. Nongkhlaw, R. Nongrum, and B. Myrboh, Synthesis of substituted hexa-3,5-dienoic acid methyl esters from conjugated dienones. Journal of the Chemical Society, Perkin Transactions 1, 2001, (11), 1300-1303. 

Collaboration/Consultancy:

  • Research Collaborations with the Department of Zoology and Department of Biotechnology, NEHU, Department of Botany, Gauhati University.

Any other

  • Resource Person in Lectures, Talks, Refresher Course, Orientation Programmes, workshops etc.
  • Chairperson of sessions in Conferences and Seminars.
  • Co-ordinator of SALTER’s- Royal Society of Chemistry (London) Science Camp, Dr. Yusuf Hamied- RSC Inspirational Chemistry Programme including teachers training Program.
  • Co-ordinator of RBPT’s workshop and training program conducted by COSME, IISER, Pune.

Reviewers for journals of national/international repute:

  1. Tetrahedron (Elsevier),
  2. Chemistry Select (Wiley)
  3. Journal of Inorganic and Organometallic Polymers and Materials (Springer)
  4. Dyes and Pigments(Elsevier)
  5. Polycyclic Aromatic Compounds (Taylor & Francis)
  6. Tetrahedron Letters (Elsevier)
  7. RSC Advances (Royal Society of Chemistry)
  8. Synthetic Communication (Taylor & Francis)+

2024, North-Eastern Hill University
Designed & developed at Bioinformatics Centre, NEHU