Prof. T. S. Basu Baul

Chemistry Department

Designation: Professor

Academic Background

  • M. Sc. University of Jabalpur (1979)
  • Ph. D. University of North Bengal (1984)

Professional Experiences

  • Visiting Scientist: Department of Chemistry, University of  Adelaide, SA, Australia (1992)
  • DST-BOYSCAST Fellow: Department of Chemistry, University of  Adelaide, Adelaide, South Australia, Australia (1995-96)
  • Visiting Scientist: Department of Chemistry, Deakin University, Geelong, Victoria, Australia (1996)
  • Post Doctoral Fellow Scientist: Institute of Inorganic Chemistry, Technical University of Aachen, RWTH, Germany (2000-01)
  • DST-EPFL Visiting Scientist: Institute of Organic Chemistry, University of Zurich, Switzerland (2010).

Academic affiliations

  • Fellow of Indian Chemical Society, Calcutta.
  • Life member of the Society of the Analytical Scientists, BARC, Mumbai.
  • Life member of the Chemical Research Society of India, Bangalore.
  • Life Member, The National Academy of Sciences, Allahabad

Research Projects

Research Interests

  • Syntheses, Structures, Reactivity and Biological properties of Organotin Compounds

There are numerous useful applications of organotin compounds including biological (e.g. anti-tumour activity) and industrial (e.g. as catalysts). The emphasis of our studies in this area is synthesis and structural, and has the specific aim of delineating the factors that dictate the adoption of a particular molecular geometry in the solid state. Such a study is essential, as bibliographic surveys have revealed that in many series of the organotin compounds and indeed, significant structural diversity, as revealed by X-ray crystallography, is found despite similarities in chemical formulae. A combination of systematic crystallographic investigations in combination with 119Sn Mössbauer spectroscopy (whenever single crystal is unavailable) has proved most potent in that definitive conclusions can be made for the system under scrutiny.

The subject of the systematic research with the aim of finding relations among the structure and static and dynamic (reactivity, catalytic and biological activity) properties of a broad area of organotin(IV) chemistry of mainly new azo- , imine and azo-imine ligand skeletons including syntheses and their characterization. The research is directed to their reactions with chemically, technically, and biologically related reactants, ligand-displacement and addition reactions, reactions with a new ligand (the way and site of coordination), and to changes in the ligand newly coordinated. The focus of our research in this area is to couple biologically active moiety with organotin so as to generate active compounds against certain biological disorders. Molecular structures are studied via FT-NMR (1H, 13C, 119Sn), FT-IR, 119Sn Mössbauer, Electrospray ionization mass spectrometry (ESI-MS) and single crystal X-ray crystallography, and others. Such techniques are being used for regular characterization, on studying their molecular transformations in a molecule itself and on molecular rearrangements, regrouping of the ligands (migrations, fluxional behaviour) of organotin complexes.

Recently, we used the concept of the preassembly of suitably architectured precursors containing two or three tin centers to generate larger molecular units. A few organotin(IV) complexes have demonstrated exciting structural diversity and biological applications. Concurrently, we are investigating the cytotoxicity and anti-tumour activity of these organotin compounds with the aim to invoke biological responses in tumours using human tumour cell lines, viz., A498 (renal cancer), WIDR (colon cancer), M19 MEL (melanoma), IGROV (ovarian cancer), H226 (non-small cell lung cancer), MCF-7 and EVSA-T (breast cancer) in collaboration with Dr. Dick de Vos, Pharmachemie BV, Haarlem, The Netherlands. In addition, some selected compounds have been tested for toxicity on second larval instar of the Aedes aegypti and Anopheles stephensi mosquito larvae in order to find better larvicides and these studies being carried out in collaboration with Prof. George Eng, Department of Chemistry and Physics, University of the District of Columbia, Washington DC, USA. More recently, we are also pursuing the toxicity studies on sea urchin (Paracentrotus lividus and Sphaerechinus granularis) development in collaboration with Prof. Lorenzo Pellerito of Dipartimento di Chimica Inorganica e Analitica "Stanislao Cannizzaro" Università di Palermo, Italy.

Academic Collaborations

Our group has well established collaborative link with Profs. Ray J. Butcher, Department of Chemistry, Howard University, USA; Frank E. Smith, Department of Chemistry and Biochemistry, Laurentian University, Canada; Eleonora Rivarola and Giuseppe Ruisi, Dipartimento di Chimica Inorganica e Analitica "Stanislao Cannizzaro" Università di Palermo, Italy; Antonin Ly?ka, Research Institute of Organic Synthesis, Czech Republic; Michal Hol?apek, Department of Analytical Chemistry, University of Pardubice, Czech Republic; Anthony Linden, Institute of Organic Chemistry, University of Zurich, Switzerland; Ulli Englert, Institut für Anorganische Chemie, Technische Hochschule Aachen, Germany; Rudolph Willem and Monique Biesemans, High Resolution NMR Centre (HNMR) and Department of Polymer Science and Structural Chemistry, Vrije Universiteit Brussel (VUB), Belgium, Herbert Höpfl, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Mexico,  Hoong-Kun Fun, School of Physics, Universiti Sains Malaysia, Malaysia, E. R. T. Tiekink, Department of Chemistry, The University of Texas at San Antonio, Texas, USA, Claudio Pettinari, Dipartimento di Scienze Chimiche, Universita di Camerino, Italy

Research Activities

Ongoing Projects:

Department of Science and Technology (DST) sponsored research project entitled "Exploration on organotin carboxylates as a viable building block for constructing homo- and hetero- nuclear supramolecules: Synthesis, structures and biological properties"

Publications

  • Diorganotin(IV) Complexes of Methyl 2-{[(E)-8-Oxo-5,8-dihydroquinolin-5-ylidene]hydrazino} benzoate, Basu Baul, T.S., Mizar, A., Ruisi, G., Tiekink, E.R.T., Z. Anorg. Allg. Chem., 638 (2012) 664-668.
  • Supramolecular aggregation patterns in mononuclear organomercury carboxylates, Basu Baul, T.S., Kundu, S., Höpfl, H.,  Tiekink, E. R. T., Z. Krystallogr., 227 (2012) 158-166.
  • An in vitro comparative assessment with a series of new triphenyltin(IV) 2-/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with anticancer activities: Structural modifications, analysis of efficacy and cytotoxicity involving human tumour cell lines, Basu Baul, T.S., Paul, A., Pellerito, L., Scopelliti, M., Duthie, A., de Vos, D., Verma, R.P., Englert, U., J. Inorg Biochem., 107 (2012) 119-128.
  • Synthesis, characterization and crystal structures of 2-[(E)-2-(4-hydroxy-3,5-dimethylphenyl) -1-diazenyl]benzoic acid and its polymeric and monomeric triorganotin(IV) complexes, Basu Baul, T.S., Paul, A., Linden, A., J. Organomet. Chem., 696 (2012) 4229-4235.
  • Molecular docking of dichlorodiorgano[N-(2-pyridylmethylene)arylamine]tin(IV) complexes with some enzymes, Basu Baul, T.S., Verma P., Singh P., J. Comput. Method. Mol. Design, 1 (2011) 11-23.
  • Dibutyltin(IV) complexes containing arylazobenzoate ligands: Chemistry, in vitro cytotoxic effects on human tumor cell lines and mode of interaction with some enzymes, Basu Baul, T.S., Paul, A., Pellerito, L., Scopelliti, M., Singh, P., Verma, P., Duthie, A., de Vos, D., Tiekink, E.R.T., Invest. New Drugs, 29 (2011) 285-299.
  • Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: Synthesis, structure, biological efficacy and QSAR studies, Basu Baul, T.S., Paul, A., Pellerito, L., Scopelliti, M., Pellerito, C., Singh, P., Verma, P., Duthie, A., de Vos, D., Verma, R.P., Englert, U., J. Inorg. Biochem., 104 (2010) 950-966.
  • In vitro cytotoxic evaluation of novel dichlorodiorgano[N-(2-pyridylmethylene)arylamine]tin(IV) derivatives in human tumor cell lines, Basu Baul, T.S., de Vos, D., Invest. New Drugs, 28 (2010) 609-614.
  • Triphenyltin(IV) 2-[(E)-2-(aryl)-1-diazenyl]benzoates as anticancer drugs: synthesis, structural characterization, in vitro cytotoxicity and study of its influence towards the mechanistic role of some key enzymes, Basu Baul, T.S., Paul, A., Pellerito, L., Scopelliti, M., Singh, P., Verma, P., de Vos, D., Invest. New Drugs, 28 (2010) 587-599.
  • An unprecedented triorganotin carboxylate structure – an isolated aggregate containing neutral and deprotonated forms of a carboxylic acid, Basu Baul, T.S., Paul, A., Tiekink, E.R.T., Z. Krystallogr., 225 (2010), 153-157.

Total Publications: 123

Patents Granted: 01

1. Basu Baul, T. S. (1998): Diethyldichloro (N-(2-pyridylmethylene)-4-toluidinetin(IV): A novel diorganotin compound having anti-tumour and anti-cancer activity. Indian Patent No. : 199990, Application No. 1838/CAL/1998 dt. 16/10/98), Date of filing: 16th Oct. 1998 and Patent granted on 17th Nov. 2006.

Applied: 01

1. Synthesis of bis (di - 2 - {(E) - (4-hydroxy-3- [(E) -(p-tolylimino) methyl] phenyl) diazenyl} benzoato) tetra- n-butyl distannoxane: An organotin(IV) compound having antitumour and anticancer activity