Prof. Ghanashyam Bez

Designation: Professor

Chemistry Department

Professional Experiences

  • Lecturer: Dibrugarh University (1999-2006)
  • Research Associate: University of Texas at San Antonio, Texas (2002-2003)
  • Research Associate: University of Kansas, Kansas (2003-2004)
  • Reader: North Eastern Hill University (2006-2009)
  • Associate Professor: North Eastern Hill University (2009-2012)
  • Professor: North Eastern Hill University (2012 onward)
  • Professor & Head: Sophisticated Analytical Instrumentation Facility (SAIF), NEHU (2015-2017)

Honors

  • Member, TARE Screening Committee, SERB, DST, New Delhi (2018-2021)
  • Guest Editor, Current Organic Chemistry, Bentham Publications
  • Subject Expert, Union Public Service Commission, New Delhi, GOI.
  • Member, Board of Post-Graduate Studies, Department of Chemistry, Rajiv Gandhi Univ., Arunachal Pradesh
  • Member, Board of Studies, Dept. of Chemistry, SMIT, Sikkim

Research Interests

  • Asymmetric synthesis 
    Enzymes and Organocatalysts are two important pillars in asymmetric synthesis. We are currently working on development of novel asymmetric organocatalyst from cheap and readily available enantiopure substances such as monosaccharides and amino acids to study their catalytic role in various carbon-carbon bond forming reactions. Simultaneously, we are working on catalytic application of various lipases in (i) kinetic resolution of alcohols and amines, and (ii) multicomponent reaction guided by enzymatic promiscuity.
  • Green synthetic methods
    Synthesis of complex molecular structures requires efficient chemical transformations. In our lab, we are working on development of new methods for synthesis of rapid assembly of complex molecules under solvent/catalyst-free conditions.
  • 1,2,4-Trioxane Chemistry
    Given the success of artemisinin as one of the most effective drugs for the treatment of malaria and its recent success against diverse tumor cell lines, efforts to achieve simpler, yet efficient 1,2,4-trioxane (the essential pharmacophore of artemisinin) core is considered very important. We are currently engaged in development of asymmetric methods for synthesis of new 1,2,4-trioxanes to study their anticancer and antimalarial efficacies.

Current group members

  1. Mr. Blamphrang Kharni
  2. Mr. Achintya Gogoi
  3. Ms. Mezhubeinu
  4. Ms. Stability Nongrum
  5. Mr. Hemanta Bordoloi
  6. Mr. Bhaskar J Gogoi

Group Alumni

  1. Dr. Khiangte Vanlaldinpuia, Assistant Professor, PUC, Mizoram University, Mizoram
  2. Dr. Lalthazuala Rokhum, Assistant Professor, NIT Silchar, Assam
  3. Dr. Pranjal P Bora, Research Scientist, Sai Life Sciences Ltd, Hyderabad, India
  4. Dr. Atoholi Sema, Assistant Professor, Phek Govt. College, Nagaland
  5. Dr. Barisha Wahlang, Assistant Professor, Shillong College, Shillong
  6. Dr. Manisha Bihani (As Joint Supervisor), Research Scientist, Sai Life Sciences Ltd, Hyderabad, India
  7. Dr. J S Momo Hmungshel Anal, Scientist D, CSIR-IIIM, Jammu
  8. Dr. Porag Bora, Research Associate, Tezpur University, India
  9. Dr. P Balagangadhar, Scientist, GVK, Hyderabad, India
  10. Dr. Grace Basumatary, Assistant Professor, Bodofa U N Brahma College, Dotma, Assam
  11. Dr. Rahul Mohanta, Lecturer, Ajmal College of Arts, Commerce & Science, Hojai, Assam
  12. Ms. Tutu Kalita (As Joint Supervisor) - (Thesis submitted)

Publications

Selected Publications

  1. Augmentation of Enantioselectivity by Spatial Tuning of Aminocatalyst: Synthesis of 2-Alkyl/aryl-3-nitro-2H-chromenes by Tandem Oxa-Michael–Henry Reaction, Mohanta R., Bez G, J. Org. Chem. (2020) 85, 4627.
  2. 1,2,3-Triazole tethered 1,2,4-trioxanes: Studies on their synthesis and effect on osteopontin expression in MDA-MB-435 breast cancer cells, Pasupuleti B G, Khongsti K, Das B, Bez G, Eur J Med Chem (2020), 186, 111908.
  3. Cu(II)-L-prolinamide: First catalytic application of metal-amidoamine complex in enantioselective Henry reaction, Mohanta R, Bez, G, Catal. Commun. (2019) 105728.
  4. Chemoselective isocyanide insertion into N-H bond using iodine-DMSO: A metal-free access to substituted ureas; Bora P., Bez G. Chem. Commun. (2018), 548363.
  5. Henry reaction in aqueous media at neutral pH, Bora, P P.; Bez, GEur. J. Org. Chem. (2013), 2013, 2922.
  6. Amberlyst A21 catalyzed chromatography-free method for multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles in ethanol; Bihani, M; Bora, P P.; Bez, G; Askari, H. ACS Sus. Chem. Engin. (2013), 1(4), 440.

Vacancy:

We are looking for highly motivated candidates with special interest in asymmetric synthesis who can apply in our PhD programme (advertised in the month of June every year).