Prof. S. Mitra

Chemistry Department

Designation: Professor

Qualifications:

  • M.Sc. Vidyasagar University (1991);
  • Ph.D. Indian Association for the Cultivation of Science (IACS) (1996)

Areas of Interest/Specialization:

  • Time-resolved Fluorescence;
  • Inclusion Complexes, Solvation Dynamics, Bio-molecular Interaction;
  • Development of Fluorescence based Enzymatic Assay Method.

In general, several aspects on the above-mentioned problems are monitored with steady state and time resolved fluorescence spectroscopy. Ultrafast photo-processes and solvent response towards the formation of the transient species are probed with transient absorption and fluorescence up-conversion techniques in collaboration with several research groups in India & abroad. The experimental results are often supported with ab-initio/DFT calculations, molecular docking and molecular dynamics (MD) simulation.

Experience:

  • JSPS Postdoctoral Fellow: Kwansei Gakuin University, Japan (1997 - 1999)
  • Postdoctoral Researcher: Katholieke University of Leuven, Belgium (1999 - 2000)
  • Visiting Fellow: Department of Chemical Science, TIFR, Mumbai (2000 - 2001)
  • Lecturer: Department of Chemistry, BITS, Pilani (2001 - 2003)
  • JSPS Invitation Fellowship: Kwansei Gakuin University, Japan (2003), 3 months.
  • Assistant Professor: Department of Chemistry, NEHU, Shillong (2003 - 2012)
  • Visiting Professor C: Kwansei Gakuin University, Japan (2006), 2 months
  • Associate Professor: Department of Chemistry, NEHU, Shillong (2012 - 2015)
  • Professor: Department of Chemistry, NEHU, Shillong (2015 - onwards)


Academic affiliations 

Member of American Chemical Society (ACS), Indian Society for Radiation & Photochemical Sciences (ISRAPS), Fluorescence Society of India, Indian Photobiology Society etc.

Research Projects

Research Projects Ongoing (01)

  1. Photophysical Studies on polypyridyl complexes: Towards the development of nanoscopic fluorescent targets (DST-SERB), Govt. of India (2019 - 2022).

Research Projects Completed (07)

  1. Excited state properties and relaxation dynamics of intramolecularly hydrogen bonded azo derivatives" Dept. of Science & Technology (DST), Govt. of India (2005 - 2008).
  2. Spectroscopic characterization of intramolecular charge transfer type polarity sensors and their use in the study of protein - surfactant interaction" Council of Scientific & Industrial Research (CSIR), Govt. of India (2005 - 2008).
  3. Construction and Multi-site Commissioning of Multiple Fluorescence Correlation Spectrometers (a single molecule biophotonic tool)" [as co-investigator, with Prof. S. Maiti of TIFR, Mumbai as chief-investigator], Dept. of Information & Technology (DIT), Govt. of India (2008 - 2011).
  4. Spectroscopy and Dynamics of Photoinduced Processes in Homogeneous and Biomimetic Environments” University grants Commission (UGC), Govt. of India (2008 – 2011).
  5. “Fluorescence Studies on Representative Intramolecular Photoprocesses in Homogeneous and Constrained Environments” Board of Research in Nuclear Sciences (BRNS), DAE, Govt. of India (2009 – 2012).
  6. “Development of Ache-inhibitor for Alzheimer’s Disease: Screening, Designing, Synthesis and Biological validation using Chemical Library and North East Indian Plants” [as co-investigator, with Prof. K. Aguan of Biotechnology Dept., NEHU as principal investigator], Department of Biotechnology (DBT), Govt. of India (2011-2014).
  7. “Spectrofluorimetric Investigation on Model Nitrogen Containing Heterocyclic Drugs and their Interaction with DNA Nucleotides” CSIR, Govt. of India (2012 – 2015).

Group members 

  • Research Associate: Dr. Dhiman Ray (DSK Post-Doctoral Fellow); E-mail: dhimanray1@gmail.com
  • Ph.D ongoing: (1) Ms. P. Baruah (praya412@gmail.com); (2) Mr. I. Rajkumar (imocharajkumar@gmail.com); (3) Ms. Anindita Bhatta (aninditabhatta01@gmail.com); (4) Mr. Deepak Chamlagai (dipakchamlagai1@gmail.com); (5) Mr. Pynskhemborlang Tep Phanrang (pynskhemphanrang@gmail.com)
  • Ph.D completed: (1) Dr. T. Sanjoy Singh (takhelsingh@gmail.com); (2) Dr. N. S. Moyon (bebemoyon@gmail.com); (3) Dr. (Mrs.) S. Phukan (smrita4m@gmail.com); (4) Dr. P. Gashnga (miki.gash@gmail.com); (5) Dr. M. M Islam (islammuhai85@gmail.com); (6) Dr. V. K. Sonu (vikash9931@gmail.com); (7) Dr. M A Rohman (rohmanmostofa@gmail.com)

 

Publications

Total number of publications: 105

The list below gives representative publications from our lab within last few years.
For details, please visit:
https://scholar.google.co.in/citations?hl=en&user=AcMxkDsAAAAJ&view_op=list_works&sortby=pubdate 

  1. “Excited state decay dynamics in 3-formyl-4-hydroxy benzoic acid: Understanding the global picture of an ESIPT driven multiple emissive species” Mostofa Ataur Rohman, Dipankar Sutradhar, Prakriti Ranjan Bangal, Asit K Chandra, and Sivaprasad Mitra, ChemistrySelect, 2019, 4, 6702 - 6712.
  2. "Fluorescence solvatochromism and modulated anticholinergic activity of novel coumarin compounds sequestered in human serum albumin nanocavities" Mostofa Ataur Rohman, Prayasee Baruah, Deboshikha Bhattacharjee, B. Myrboh, and Sivaprasad Mitra, New Journal of Chem., 2019, DOI: 10.1039/C9NJ03293B.
  3. “Specific solvent effect on the photophysical behavior of substituted chromones: A combined fluorescence, DFT and MD study” Mostofa Ataur Rohman, Prayasee Baruah, Semen O. Yesylevskyy, and Sivaprasad Mitra, Chemical Physics, 2019, 517, 67 – 79. DOI: 10.1016/j.chemphys.2018.09.042
  4. “Novel Coumarin Derivatives as Potent Acetylcholinesterase Inhibitors: Insight into Efficacy, Mode and Site of Inhibition”, Prayasee Baruah, Grace Basumatary, Semen O. Yesylevskyy, Kripamoy Aguan, Ghanashyam Bez, and Sivaprasad Mitra, J. Biomolecular Structure and Dynamics, 2018. DOI: 10.1080/07391102.2018.1465853.
  5. “Interaction of caffeine and sulfadiazine with Lysozyme adsorbed at colloidal metal nanoparticle interface: Influence on drug transport ability and antibacterial activity”, Vikash K. Sonu, Imocha Rajkumar, Kaushik Bhattacharjee, S. R. Joshi, and Sivaprasad Mitra, J. Biomolecular Structure and Dynamics, 2018. DOI: 10.1080/07391102.2018.1426497.
  6. “Serum albumin interaction with xanthine drugs at nano-bio interfaces: A combined multi-spectroscopic and molecular modelling approach”, Vikash K. Sonu, Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, and Sivaprasad Mitra, J. Mol. Liq., 2017, 242, 919 - 927.
  7. “Photophysical behavior of systematically substituted (di-2-pyridylaminomethyl) benzene ligands and its Re(l) complexes: A combined experimental and theoretical approach”, M. A. Rohman, D. Sutradhar, S. Sangilipandi, K. Mohan Rao, Asit K. Chandra, Sivaprasad Mitra, J. Photochem. Photobiol. A: Chemistry, 2017, 341, 115 – 126.
  8. “Cholinergic inhibitors replace thioflavin-T from acetylcholinesterase binding pocket: A potential fluorescence based molecular switch”, Mullah Muhaiminul Islam, and Sivaprasad Mitra, Chem. Phys. Letts. 2016, 664, 63 – 69.
  9. “Lysozyme binding ability toward psychoactive stimulant drugs: Modulatory effect of colloidal metal nanoparticles” Vikash K. Sonu, Mullah Muhaiminul Islam, Mostofa Ataur Rohman, and Sivaprasad Mitra, Colloids and Surfaces B: Biointerfaces, 2016, 146, 514 – 522.
  10. “Fluorescence properties and sequestration of peripheral anionic site specific ligands in bile acid hosts: Effect on acetylcholinesterase inhibition activity” Mullah Muhaiminul Islam, Kripamoy Aguan, and Sivaprasad Mitra, J. Photochem. Photobiol. B. Biology, 2016, 158, 192 – 201.
  11. “Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease” Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhatacharjee, Kripamoy Aguan, and Sivaprasad Mitra, Chemico-Biological Interactions 2016, 249, 1 – 9.
  12. “Intramolecular charge transfer in coumarin based donor-acceptor systems: Formation of a new product through planar intermediate” S. Phukan, M. Saha, A. K. Pal, A.C. Bhasikuttan, and S. Mitra, J. Photochem. Photobiol. A: Chemistry, 2015, 303, 67 – 79.
  13. “Specific Solvent Effect on Lumazine Photophysics: A Combined Fluorescence and Intrinsic Reaction Coordinate Analysis”, N. S. Moyon, P. M. Gashnga, S. Phukan, S. Mitra, Chem. Phys., 2013, 421, 22 - 31.
  14. “Fluorescence Modulation and Associative Behavior of Lumazine in Hydrophobic Domain of Micelles and Bovine Serum Albumin” N. S. Moyon, M. M. Islam, S. Phukan, S. Mitra, J. Photochem. Photobiol. B: Biology, 2013, 121, 37 - 45.
  15. “Luminol Fluorescence Quenching in Bio-mimicking Environments: Sequestration of Fluorophore in Hydrophobic Domain” N. S. Moyon and Sivaprasad Mitra, J. Phys. Chem. B. 2011, 115, 10163 - 10172.
  16. "Fluorescence Solvatochromism in Lumichrome and Excited State Tautomerization: A Combined Experimental and DFT Study" N. S. Moyon and Sivaprasad Mitra, J. Phys. Chem. A. 2011, 115, 2456 - 2464.

Invited Talks in Conferences/Seminars

Serial No. Title Seminar details
1 Time-Resolved Studies on ESIPT Systems: Targeted Manipulation of Multiple Emissive States National workshop on Fluorescence & Raman Spectroscopy (FCS -2017) held at IIT-Guwahati,17-21 Dec, 2017.
2 Fluorescence Modulation in Alloxazines: Exploring the Mechanism of Water Catalysed Riboflavin Biosynthesis Pathway Trombay Symposium on Radiation & Photochemistry (TSRP), Jan 6-9, 2014
3 Photochemistry of substituted 1,4-dihydropyridines: Formation of ICT state through 1,3-H migration National Conference on Photosciences: Contemporary Challenges and Future Perspectives, Dec 12-14, 2013. Indian Photobiology Soc.
4 Intramolecular charge transfer in cinnamic acid derivatives: Fluorescence modulation in organized assemblies National Symposium in Radiation & Photochemistry (NSRP – 2013)
March 20-22, 2013, ISRAPS
5 Photochemistry of alloxazine derivatives and their interaction with serum albumins National workshop on “Fluorescence Correlation  Spectroscopy & Biophotics” (FCS -2012) held on  3-7 December, 2012 in SINP and IICB, Kolkata 

Organization of Conferences/Symposia:

  • Convener of “National Workshop on Fluorescence Correlation Spectroscopy & Biophotonics (FCS-2010)” held at North-Eastern Hill University, Shillong, Nov 8 -13, 2010.
  • Vice-Chairman of the local organising committee for the BRNS-AEACI Ninth School on Analytical Chemistry (SAC-9) held at Atomic Minerals Directorate, NE Region, Shillong during Oct 27 – Nov 03, 2014.    
  • Convener of National Seminar on contemporary Challenges in Chemistry (NSC3-2018) held at North-Eastern Hill University, Shillong, Nov 20-21, 2018.