Teaching and Research experience: 15+ years

Ph.D. thesis title: Dietary and hormonal modulation of acetylcholinesterase in mice as a function of age

Research Specialization: Molecular Biology, Biochemistry, Endocrinology

Research interest:

Our research aims to shed light on the changes in cellular and molecular pathways underpinning the aging process. We strive to use this knowledge to translate and develop novel therapeutic strategies to treat/ameliorate age-associated diseases. By posing fundamental questions about differences in rates and risks for pathological conditions associated with aging, we employ Caenorhabditis elegans model organism, cell-based assays, and rodents for various in vitro and in vivo experimentations.

Current research topics:

1. Understanding the role of Klotho protein in chronic kidney disease (CKD) and its synergistic modulation by endocrine and natural principle components
2. Study of alpha 7 nicotinic acetylcholine receptor as a function of age in different model systems: its modulation in acute and chronic kidney disease
3. Study of AMPK in association with autophagy and oxidative stress in different model systems: its implications in aging and chronic kidney disease

Employment details:

 Awards/ Achievements:

• Awarded best teacher merit certificate in the Department of Biochemistry and Molecular Biology by Pondicherry University, India, 2015.
• Best oral presentation award at Indo-US conference on “Recent biochemical approaches in therapeutics, RBAT IX”, organized by University of Kerela & University of Wisconsin from February 1-3, 2023.
• Excellent article award 2018 by Chinese Society of metals for original research article in the Journal of Material Science and Technology, Elsevier (Impact Factor 10.32).
• Awarded best poster presentation in "International Conference on Applications of Biotechnology and Nanotechnology (ICBN 2019" organized by School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India in association with University of Missouri, USA from 30th September and 1st October 2019.
• Selected for UGC-Raman fellowship for postdoctoral studies in USA for the year 2015-16 by UGC, Government of India.
• Best poster presentation in International symposium on Aging (ISOA-2012) and 16th Biennial Conference of Association of Gerontology (India) on "Aging and stress response: A comparative studies based on acetylcholinesterase" held in October 1-3, 2012 in NEHU, Shillong, India.

Society membership:

Life member- Society of Gerontology, India.

M.Sc. dissertation Supervised/Supervising: 28/3

Ph.D. thesis Supervised/Supervising : 2/3

Research Projects

Research Grants:

Publications

• Ramatchandirane M, Rajendran P, Athira MP, Suchiang K. (2025) Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway. Biogerontology 26:25. (Springer; Impact factor: 4.4).
• Mohanty SK, Mohanty AK, Kumar MS, Suchiang K. (2024) Triiodothyronine enhances various forms of kidney-specific Klotho protein and suppresses the Wnt/β-catenin pathway: Insights from in-vitro, in-vivo and in-silico investigations. Cellular Signalling 120:111214. (Elsevier; Impact factor: 4.3).
• Mohanty SK, Suchiang K. (2023) Baicalein mitigates oxidative stress and enhances lifespan through modulation of Wnt ligands and GATA factor: ELT-3 in Caenorhabditis elegans. Life Sciences 329:121946. (Elsevier; Impact factor: 5.2).
• Kumar S, Akhila PV, Suchiang K. (2023) Hesperidin ameliorates Amyloid-β toxicity and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans through acr-16 mediated activation of the autophagy pathway. Free Radical Biology and Medicine. 2:366-380.
• Kumar S, Praneet NS, Suchiang K. (2022) Lactobacillus brevis MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in Caenorhabditis elegans via the DAF-16 pathway. Free Radical Research 16:1-17. (Taylor & Francis: Impact factor: 4.3).
• Anju VT, Busi S, Kumar S, Suchiang K, Kumavath R, Ranganathan S, Ampasala DR, Dyavaiah M. (2022) Alantolactone modulates the production of quorum sensing mediated virulence factors and biofilm formation in Pseudomonas aeruginosa. Biofouling 38:331-347. (Taylor & Francis: Impact factor: 3.8).
• Mohanty SK, Suchiang K. (2021) Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans. Biogerontology 22:397–413. (Springer: Impact factor: 4.3).
• Jayachandra N, Bhagat E, Suchiang K, Sadras SR. (2015) Comparative study of antioxidant and catalytic activity of silver and gold nanoparticles synthesized from Costus pictus leaf extract. Journal of Materials Science & Technology 31:986–994. (Elsevier; Impact factor 11.2).
• Lakra AK, Ramatchandirane M, Kumar S, Suchiang K, Arul V. (2021) Physico- chemical characterization and aging effects of fructan exopolysaccharide produced by Weissella cibaria MD2 on Caenorhabditis elegans. LWT, 143:111100. (Elsevier; Impact factor: 6.1).
• Mohapatra AR, Lakshmanan D, Mahesh R, Suchiang K, Jeevaratnam K. (2021) Characterization and Cytotoxic Evaluation of Bacteriocins Possessing Antibiofilm Activity Produced by Lactobacillus plantarum SJ33. International Journal of Peptide Research and Therapeutics, 1-15. (Elsevier; Impact factor: 2.2).
• Mahesh, R., Ilangovan, P., Nongbri, D. Suchiang K. (2021) Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans. Indian Journal of Microbiology 61, 404–416. (Springer; Impact factor: 2.5).
• Anju VT, Busi S, Ranganathan S, Ampasala DR, Kumar S, Suchiang K, Kumavath R, Dyavaiah M. (2021) Sesamin and sesamolin rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through the attenuation of quorum sensing regulated virulence factors. Microbial Pathogenesis 155:104912. (Elsevier: Impact factor 3.9).
• Suchiang K and Sharma R. (2016) Age-dependent modulation of fasting and long- term dietary restriction on acetylcholinesterase in non-neuronal tissues of mice. Molecular and Cellular Biochemistry 419:135–145. (Springer; Impact factor 3.8).
• Suchiang K and Sharma R. (2012) Dietary restriction regulates brain acetylcholinesterase in female mice as a function of age. Biogerontology 12: 581- 589. (Springer; Impact factor 4.3).
• Hnamte S, Parasuraman P, Ranganathan S, Ampasala DR, Reddy D, Kumavath RN, Suchiang K, Mohanty SK, Busi S. (2019) Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach. Microbial Pathogenesis 131:128-134. (Elsevier; Impact factor 3.8).
• Rajkumari J, Borkotoky S, Reddy D, Mohanty SK, Kumavath R, Murali A, Suchiang K, Busi S. (2019) Anti-quorum sensing and anti-biofilm activity of 5- hydroxymethylfurfural against Pseudomonas aeruginosa PAO1: Insights from in vitro, in vivo and in silico studies. Microbiology Research 226:19-26. (Elsevier; Impact factor 5.4).
• Rajkumari J, Borkotoky S, Muralib A, Suchiang K, Mohanty SK, Busi S. (2018). Cinnamic acid attenuates quorum sensing associated virulence factors and biofilm formation in Pseudomonas aeruginosa PAO1. Biotechnology Letters 1-14. (Impact factor 2.7).
• Rajkumari J, Borkotoky S, Muralib A, Suchiang K, Mohanty SK, Busi S. (2018). Attenuation of quorum sensing controlled virulence factors and biofilm formation in Pseudomonas aeruginosa by pentacyclic triterpenes, betulin and betulinic acid. Microbial Pathogenesis 118:48-60. (Elsevier; Impact factor 3.7).
• Suchiang K and Sharma R. (2007). Curcumin ameliorates methionine induced oxidative stress on acetylcholinesterase activity on mouse brain. Supplement: Annals of neuroscience: An official journal of the Indian Academy of Neurosciences, 14, p32.

Book chapters:

• Mohanty SK., Veerabhadrappa B., Majhi A., Suchiang K., Dyavaiah M. (2024) Age-related disease: Kidneys In: Michael Fossel (eds) Aging:How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases, Academic Press, USA, Chapter 6, 91-117. https://doi.org/10.1016/B978-0-443-15500-0.00003-7, [ISBN-10‏ :‎ 0688153844].
• Suchiang K., Mahesh R. (2020) Caenorhabditis elegans: A Tool for Antimicrobial Drug Discovery. In: Siddhardha B., Dyavaiah M., Syed A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. 559–596. https://doi.org/10.1007/978-981-15-1695-5_29, [ISBN978-981-15-1694-8].
• Kumar S., Suchiang K. (2020) Caenorhabditis elegans: Evaluation of Nanoparticle Toxicity. In: Siddhardha B., Dyavaiah M., Kasinathan K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore 333–369. https://doi.org/10.1007/978-981-15-1702-0_17, [ISBN 978-981-15-1701-3].
• Mahesh R., Suchiang K. (2020) Caenorhabditis elegans: Evaluation of Nanoparticle Toxicity. In: Siddhardha B., Dyavaiah M., Kasinathan K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore. 139-175. https://doi.org/10.1007/978-981-15-1702-0_17,  [ISBN 978-981-15-1701-3].

Academic/Administrative responsibilities:

• Member of the School Board in Life Sciences, Pondicherry University 2023-2026
• Member Board of studies UG (Biochemistry), Pondicherry University, 2019-2022
• Member Board of studies PG (Biochemistry and Molecular Biology), Pondicherry University, 2021-2024
• Doctoral committee member for 12 Ph.D. Scholars of different Universities and Medical Institutions.
• Academic coordinator for Department of Biochemistry and Molecular Biology, Pondicherry University, 2022-24
• Member for the design and framing of a new curriculum for UG, PG, and Ph.D. in biochemistry programs at Pondicherry University, 2019
• Coordinator for an invited lecture on "Ubiquitin and Stem cell-A personal account" by Prof. Krishnamoorthy Kannan, Former Vice Chancellor of Nagaland University
• Coordinator for an invited lecture on "Ageing: from hemodynamics to hormesis" by Prof. Suresh Rattan, Aarhus University, Denmark
• Organizing committee member for National seminar on "current topics in Biological research" held at Pondicherry University on October 20, 2017
• Organizing committee member for a workshop on "Advanced protein detection techniques" held at Pondicherry University on October13, 2017.
• Organizing committee member for National seminar on “Current topics in biological research” held at Pondicherry University on October 20,2017
• Organizing committee member for the National Science Day seminar held at Pondicherry University on Feb 24, 2017
• Co-organizing Secretary for "Bio-Gene-Sys 2017" held at Pondicherry University on 28th February 2017
• Faculty Adviser 2018-19 for Pondicherry University North East India Community (PUNEIC)
• Organizing committee member of International virtual conference on drug discovery and translational research hosted by the Department of Biochemistry & Molecular biology, Pondicherry University during February 25-26, 2021.

Conferences/ Workshops attended:

• Presented paper on “Combined Triiodothyronine and Baicalein upregulate Klotho protein with ameliorative effects in chronic kidney disorder and its complications in aged BALB/c mice” at Indo-US conference on “Recent biochemical approaches in therapeutics, RBAT IX” organized by University of Kerela & University of Wisconsin, USA from February 1-3, 2023.
• Presented paper on “Antiaging,  anti-diabetic  and  hepatoprotective  activity  of Phlogaganthus tyrsiflorus Nees in female mice as a function of age” at International Conference on Advances in Medical and Industrial Biotechnology. ICAMIB, conducted by Sathyabama Institute of Science and Technology, Chennai, India, from 20- 22 March, 2019.
• Presented paper on "Antiageing, Antioxidant and Neuroprotective activity of Astaxanthin in Caenorhabditis elegans model organism as a function of age" in International Conference on Applications of Biotechnology and Nanotechnology (ICBN 2019" organized by School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India in association with University of Missouri, USA from 30^th September -1^st October 2019.
• Presented paper on "Comparative studies of Couroupita guianesis chemical composition: Implications on attenuation of pro???oxidant and pathogen virulence in Caenorhabditis elegans" at the 9^th National Academy of Biological Sciences Conference held at Madurai Kamaraj University, Madurai on 11-12 August, 2016
• Presented paper on "Delineation of genetic and biochemical events in aging phenomena using Caenorhabditis elegans model organism" at National seminar on "Drug discovery and cancer therapy" conducted by Department of Biochemistry and molecular biology Pondicherry University, Puducherry, India from 25-26 February, 2016.
• Presented paper on "Aging and stress response: A comparative studies based on acetylcholinsterase in mice as a function of age" at National seminar on "Drug discovery and cancer therapy" conducted by Department of Biochemistry and molecular biology Pondicherry University, Puducherry, India from 25-26 February, 2016.
• Participate at the World Congress of Gerontology and Geriatrics 3rd International Conference on "Healthy ageing in the changing world" held at J.N. Tata Auditorium Indian Institute of Sciences Bengaluru, India from 17-19 November, 2014.
• Presented a poster entitled "Aging and stress response: A comparative studies based on acetylcholinsterase in mice as a function of age" in the International symposium on Aging (ISOA-2012) and 16th Biennial Conference of Association of Gerontology (India) held in October 1-3, 2012 in NEHU, Shillong, India.
• Presented a poster at the 79th Annual meeting of the Society of Biological Chemists (India) on "Regulation of biochemical and cellular processes in Diverse Systems" held during 13th -15th December 2010 at Indian Institute of Science, Bangalore, India.
• Poster presentation at the International Symposium on Advances in Neurosciences, on "Curcumin ameliorates methionine induced oxidative stress on acetylcholinesterase activity in mouse brain." 22-25 November 2007 at Banaras Hindu University on
• Lecture on" Acetylcholinesterase activity in different tissues of mice as a function of age" at National Seminar on' Adaptation Biochemistry' held on 22-23 March, 2007 organized by the Department of Biochemistry, Nehu, Shillong.