Prof. Rajeshwar N. Sharan

Biochemistry Department

Designation: Professor

Qualifications:

  • B.Sc. (Hons.), Patna University
  • M.Sc., JNU
  • Ph.D., JNU

Areas of Interest/Specialization: 

Cancer and Radiation Molecular Biology (Prof. Sharan is a Molecular Biologist and Biochemist by training with over 3 decades of research experience in the field of betel (Areca) nut & chemical induced carcinogenesis, and molecular mechanisms of radiation induced damage to DNA & its repair with expertise in biomarker discovery for cancer and radiation damage assessment or for their clinical applications. Since last few years, he has also developed keen interest in the field of tobacco related cancer and its harm reduction).

Experience: 

Over 35 years

Publication/Books:

Total publications: 111 [Books – 6, including 1 text book adaptation, 2010 International Edition and 1 with e-book version; Full length research papers – 105 (including 11 reviews)]. ‘H’ Index = 13; Total citations > 1100; Cumulative IF = 275; Average IF @ 3; Number of reviews = 11; Number of papers in journals with IF greater than 2 = 50 [Details in Google Scholar under ‘R. N. Sharan/Sharan, RN/Sharan, Rajeshwar’].

Fifteen gene/NT sequences have also been published on GenBank repository.

Research Projects:

  • Eleven national agency (BRNS, CSIR, DOEn, DRDO, DST, ICMR, UGC, UPE – I, etc.) funded and four international research agency (CRP of IAEA Vienna; PUI project of IAEA-Japan; DLR, Germany (Indo-German Bilateral Cooperation) and TWAS, Italy) funded research projects have been successfully completed.
  • Currently, an international Co-ordinated Research Project (CRP) funded by the International Atomic Energy Agency (IAEA), Vienna (Austria) is ongoing (2017 - 2021) (IAEA Research Contract # 22218).

Awards (if any): Nil

Ph. D. Awarded/Supervised:

Sixteen Ph. D. degrees and one M. Phil. degree – awarded; one Ph. D. scholar (INSPIRE Fellow) is currently working in the domain of cancer biomarker clinical study. Three PDFs worked in my lab. and over two dozen under- and post-graduate interns from India and abroad have been trained in my lab.

Administrative responsibilities undertaken

Besides having discharged the usual administrative responsibilities that are assigned from time to time at NEHU as per seniority, some of the additional administrative responsibilities (current and former) include (a) Director, Design Innovation Centre (DIC); (b) Member, EC of National Council of Science Museum; (c) Member, Steering Committee of DBT-NER for HRD; (d) Visitor’s nominee on the EC of Assam University, Silchar; (e) Visitor’s nominee, Court, BHU, Varanasi; (f) Dean, Student’s Welfare, NEHU (2 successive terms); (g) Administrative in-charge for NEHU Data and Voice Network (NDVN); (h) Program-Co-ordinator, NSS Cell, NEHU; and (i) President, Indian Society for Radiation Biology (ISRB), among many others.

Academic affiliations

Life Member of

  1. Indian Society for Training & Development;
  2. Indian Society for Radiation Biology (ISRB);
  3. Indian Association for Cancer Research (IACR);
  4. Indian Science Congress Association (ISCA);
  5. Indian Complex Systems Society (ICSS);
  6. Asian Association of Radiation Research (AARR), etc.

Papers presented in Conferences/Seminars: Numerous.

Collaboration/Consultancy (if any):

Currently collaborating with International Agency for Atomic Energy (IAEA), Vienna (Austria); Dr. B. Barooah Cancer Institute (BBCI), Guwahati; North East Cancer Hospital & Research Institute (NECHRI), Jorabat; Department of Chemistry, NEHU; Department of Nano Technology, NEHU and Center for Health Research and Education (CHRE), UK, etc.

Patents

One Indian patent # 302099 granted and one (# 10193) under process.

Any other:

Presently I also serve as Director, Design Innovation Center (DIC), NEHU.

Publications

Representative Publications

BOOK

  1.  “Molecular and Cell Biology” – Schaum’s Outline series. 2010. W. D. Stansfield, J. S. Colomé, R. J. Cano & R. N. SHARAN (Special Indian Adaptation Edition), Tata McGraw Hill Education Pvt. Ltd., New Delhi [ISBN (13): 978-0-07-015379-0].

ORIGINAL CONTRIBUTIONS

  1. P. HANDE, R. SHARAN, O. BELYAKOV. Strengthening biological dosimetry in member states of the international atomic energy agency. Genome Integr. 2016;7:9 - EDITORIAL (DOI: 10.4103/2041-9414.197170).
  2. S. NONGRUM, S. THANGMINLAL VAIPHEI, J. KEPPEN, MANDAHAKANI KSOO, E. KASHYAP & R. N. SHARAN. Identification and preliminary validation of radiation response proteins(s) in human blood for a high throughput molecualr biodosimetry technology for the future Genome Integr. 2017;8:5 (DOI: 10.4103/2041-9414.198910).
  3. R. N. SHARAN, S. THANGMINLAL VAIPHEI, SAIBADAIAHUN NONGRUM, JOSHUA KEPPEN, & MANDAHAKANI KSOO. Consensus referecne gene(s) for gene expression studies in human cancers: End of the tunnel visible? (Review). Cell. Oncol. 38 (6), 419-431, 2015 (DOI: 10/1007/s13402-015-0244-6).
  4. R. N. SHARAN, R. MEHROTRA, YASHMIN CHOUDHURY & K. ASOTRA. Association of betel nut with carcinogenesis: Revisit with a clinical perspective (a systematic review). PLoS ONE 7(8): e42759, 2012 (doi:10.1371/journal.pone.0042759) Description: http://cdn.f1000.com.s3.amazonaws.com/images/badges/badgef1000.gif F1000 Recommendations, Dissents and Comments for [Sharan RN et al., PLoS ONE 2012, 7(8):e42759]. Faculty of 1000, 13 Oct 2012; F1000.com/717954776.
  5. R. N. SHARAN & YASHMIN CHOUDHURY. Betel nut and susceptibility to cancer. Solicited contribution (multi-author refereed review) for a monograph titled “Environment Factors, Genes, and Development of Human Cancers” edited by D. Roy and M. T. Dorak, Chapter 15, pp. 200-228, Springer Science + Business Media, USA, 2011 (doi 10.1007/978-1-4419-6752-7_15).
  6. R. O. LAKADONG, A. C. KATAKI & R. N. SHARAN. ADP-ribose polymer - a novel and general biomarker of human cancers of head & neck, breast, and cervix. Mol. Cancer, 9:286, 2010 (doi:10.1186/1476-4598-9-286).
  7. R. N. SHARAN. Poly-ADP-ribosylation in cancer, In: Cancer Epigenetics (multi-author refereed review) edited by Trygve Tollefsbol, Chapter 15, pp. 265-279, CRC Press, USA, 2009.
  8. *R. N. SHARAN, H. RYO & T. NOMURA. Critical role of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of rejoining following g-radiation induced damage to pMTa4 DNA in E. coli. Int. J. Radiat. Biol., 83, 89-97, 2007 (doi: 10.1080/09553000601121140).
  9. R. N. SHARAN. Preparedness to Respond to Possible Acts of Nuclear Terrorism: Some Strategies and Recommendations. Int. J. Radiat. Biol., 79, 217-219, 2003.

Patents and International recognition of Professor R. N. Sharan

  1. The final patent # E-2/1772/2014/KOL pertaining to the provisional application (# 486/KOL/2013) on a “bio-marker and method of molecular bio-dosimetry” under International Treaties and Conventions (ITC) has been filed at Kolkata in 2014.
  2. A new final patent application # 839/KOL/2013 on a “process for wastewater treatment” under International Treaties and Conventions (ITC) has been filed at Kolkata in 2013 (published).
  3. One provisional patent application # 3162/MUM/2011 under International Treaties and Conventions (ITC) filed in 2011.
  4. A tripartite agreement signed in November 2011 between IndSwift Pharma. Co. Ltd, NEHU and Prof. Sharan on cancer detection technology.
  5. One Indian patent on blood based cancer detection technology was filed in 2009 under PAT/4.18.2/08044 through NRDC (published and under examination).
  6. Poly-ADP-ribosylation (PAR) of cellular proteins based tool for early cancer detection and for mass screening of population; concept recognition by UGC-UNDP-APCTT-SPI as ‘emerging technologies and potentials of research