0364 2307930 - 2341
9436766999
ttripathi@nehu.ac.in
timir.tripathi@gmail.com
Designation: Professor
Department: Zoology
Teaching Experience: 15+ years (CSIR-JRF/SRF)
Research Experience: 19+ years
Research Specialization: Molecular Biology, Biochemistry, Biophysics
Research Area Focus:
Research Data (as of June 2024):
| Research Publications | 105 |
| Textbooks Authored: | 02 |
| Books Edited: | 06 |
| Book Chapters | 21 [20- English, 01- Hindi] |
| Total Impact Factor | 488.078 |
| Total Citations | 3400+ |
| h-index | 32 |
| i10 index | 71 |
| Ph.D. Awarded | 06 |
|
M.Sc./M.Tech. Trained:
|
31/03 |
| Research Projects | 11 (as PI), 03 (as Co-PI) |
About Dr. Tripathi:
Prof. Timir Tripathi is a Professor of Molecular Biology in the Department of Zoology, School of Life Sciences, NEHU, Shillong. Earlier, he served as the Regional Director of Indira Gandhi National Open University (IGNOU), Kohima, Nagaland (2022-2023), where he contributed significantly to educational leadership, governance, and management. Before assuming this administrative position, he was Senior Assistant Professor and Principal Investigator at the Department of Biochemistry, NEHU, Shillong (2009-2022). He holds a Ph.D. from Jawaharlal Nehru University, New Delhi, while working at the Central Drug Research Institute, Lucknow. He was a visiting faculty at ICGEB, New Delhi, India, and Khon Kaen University, Thailand.
His research interests lie in the field of protein-substrate interaction and dynamics and understanding the roles of non-catalytic domains in regulating the catalytic activity of proteins. His primary focus is studying the conformational dynamics, interaction, and stabilization of the complexes formed by intrinsically disordered neuropathological protein aggregates, their properties of liquid-liquid phase separation, interaction, and roles in nucleocytoplasmic transport in neurodegenerative diseases. In addition, he is interested in analyzing the structural and functional characteristics of drug target proteins from the helminth liver fluke parasite Fasciola gigantica to identify new therapeutic strategies.
He has received several awards, including Prof. B.K. Bachhawat Memorial Young Scientist Lecture Award (2020) by the National Academy of Sciences, India, ISCB-Young Scientist Award (2019), ICMR-Shakuntala Amir Chand Prize (2018), BRSI-Malviya Memorial Award (2017), DST-Fasttrack Young Scientist Award (2012), DBT-Overseas Associateship Award (2012), Dr. D.M. Bose Award (2008), etc. He is an Associate Fellow of the Indian National Science Academy (INSA), New Delhi, and an elected member of the National Academy of Sciences, India, Royal Society of Chemistry, and Royal Society of Biology, UK. He has handled several research grants as a principal investigator from various national and international funding agencies, including DST-Russian Foundation for Basic Research, UGC-Israel Science Foundation, DBT, SERB, DHR, and ICMR. He has published over 100 research papers, reviews, commentaries, viewpoints, outlooks, and editorial articles in international journals and published several book chapters. He has edited five books and authored two textbooks for undergraduate and postgraduate students. Currently, he serves as the editor of the International Journal of Biological Macromolecules and is the editorial board member of Scientific Reports and Acta Tropica.
Textbooks:
02. Tripathi, T*. (2024) Chromatography and Centrifugation Methods: A Beginner's Handbook. Astral International (P) Ltd, New Delhi. Pp. 1-206 [ISBN: 978-93-5461-731-7]. (Amazon Link: https://amzn.to/3F22kAH)
01. Tripathi, T*. (2023) Introduction to Spectroscopic Methods. Astral International (P) Ltd, New Delhi. Pp. 1-170 [ISBN: 978-93-5461-699-0]. (Amazon Link: https://amzn.to/3HU9Pfs)
Books:
06. Tripathi, T*. and Uversky, V.N. Editors (2024) The Three Functional States of Proteins: Structured, Intrinsically Disordered and Phase Separated. Academic Press, USA. [ISBN: 978-044-32-1809-5].
05. Saudagar, P., and Tripathi, T*. Editors (2023) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer, Singapore. Pp. 1-287 [ISBN: 978-981-99-2078-5].
04. Saudagar, P., and Tripathi, T*. Editors (2023) Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics. Academic Press, USA. Pp. 1-558 [ISBN: 978-032-39-9127-8].
03. Singh, D.B., and Tripathi, T*. Editors (2022) Protein-based Therapeutics. Springer Nature Singapore. Pp. 1-384 [ISBN: 978-981-19-8248-4]
02. Tripathi, T*. and Dubey, V.K. Editors (2021) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. Pp. 1-714 [ISBN: 978-032-39-0264-9]
01. Singh, D.B., and Tripathi, T*. Editors (2020) Frontiers in Protein Structure, Function, and Dynamics. Springer Singapore. Pp. 1-458 [ISBN 978-981-15-5529-9].
Research Publications:
105. Subedi, S., Nag, N., Shukla, H., Padhi, A.K., and Tripathi, T*. (2024) Comprehensive analysis of liquid-liquid phase separation propensities of HSV-1 proteins and their interaction with host factors. J Cell Biochem doi: 10.1002/jcb.30480.
104. Padhi, A.K., Kalita, K., Maurya, S., Poluri, K.M., and Tripathi, T*. (2023) From de novo design to redesign: Harnessing computational protein design for understanding SARS-CoV-2 molecular mechanisms and developing therapeutics. J Phys Chem B 127(41): 8717-8735.
103. Joshi, A., Maurya, S., Mahale, A., Rath, S.L., Tripathi, T*., and Padhi, A.K. (2023) Delineating the structure-dynamics-binding differences among BA.1, BA.4/5, and BF.7 SARS-CoV-2 variants through atomistic simulations: Correlation with structural and epidemiological features. ACS Omega 8(41): 37852-37863.
102. Tripathi, T*. (2023) Advances in vaccines: Revolutionizing disease prevention. Sci Rep 13(1): 11748.
101. Doharey, P.K., Verma, P., Dubey, A., Singh, S.K., Kumar, M., Tripathi, T., Alonazi, M., Siddiqi, N.J., and Sharma, B. (2023) Biophysical and in-silico studies on the structure-function relationship of Brugia malayi protein disulfide isomerase. J Biomol Struct Dyn 43(3): 1533-1543.
100. Nag, N., and Tripathi, T*. (2023) Nup98 mislocalization is a common feature in primary tauopathies. Brain Commun 5(2): fcad097.
99. Kalita, P., Tripathi, T., and Padhi, A.K. (2023) Computational protein design for COVID-19 research and emerging therapeutics. ACS Cent Sci 9(4): 602-613.
98. Koner, D., Nag, N., Kalita, P., Padhi, A.K., Tripathi, T*., and Saha, N. (2023) Functional expression, localization, and biochemical characterization of thioredoxin glutathione reductase from air-breathing magur catfish, Clarias magur. Int J Biol Macromol 230: 123126.
97. Joshi, A., Tripathi, T., Singh, S.K., and Padhi, A.K. (2023) Computational approaches for development of engineered therapeutics against SARS-CoVâ?Â2. Biochemistry 62: 669-671.
96. Padhi, A.K., and Tripathi, T*. (2023) A comprehensive protein design protocol to identify resistance mutations and signatures of adaptation in pathogens. Brief Funct Genomics 22(2): 195-203.
95. Nag, N., and Tripathi, T*. (2023) Tau–FG-nucleoporin98 interaction and impaired nucleocytoplasmic transport in Alzheimer’s disease. Brief Funct Genomics 22(2): 161-167.
94. Padhi, A.K., and Tripathi, T*. (2022) Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomes. Biochem Biophys Res Commun 629: 54-60.
93. Nag, N., and Tripathi, T*. (2022) Mislocalization of Nup62 contributes to TDP-43 proteinopathy in ALS/FTLD. ACS Chem Neurosci 13(17): 2544-2546.
92. Dkhar, D.S., Kumari, R., Mahapatra, S., Divya., Kumar, R., Tripathi, T*., and Chandra, P. (2022) Antibody-bioreceptor bioengineering and its implications in designing bioelectronic devices. Int J Biol Macromol 218: 225-242.
91. Kalita, P., and Tripathi, T*. (2022) Methodological advances in the design of peptide-based vaccines. Drug Discov Today 27(5): 1367-1380.
90. Padhi, A.K., and Tripathi, T*. (2022) High-throughput design of symmetrical dimeric SARS-CoV-2 main protease: Structural and physical insights into hotspots for adaptation and therapeutics. Phys Chem Chem Phys 24(16): 9141-9145.
89. Subedi, S., Nag, N., Sasidharan, S., Saudagar, P., and Tripathi, T*. (2022) Amyloid cross-seeding: Mechanism, implication, and inhibition. Molecules 27(6): 1776.
88. Nag, N., and Tripathi, T*. (2022) Cross-seeding with homologous sequences alters amyloid aggregation kinetics and fibril structure. ACS Chem Neurosci 13(5): 537-539.
87. Nag, N., Sasidharan, S., Uversky, V.N., Saudagar, P., and Tripathi, T*. (2022) Phase separation of FG-nucleoporins in nuclear pore complexes. Biochim Biophys Acta Mol Cell Res 1869(4): 119205.
86. Raj, S., Sasidharan, S., Tripathi, T., and Saudagar, P. (2022) Biofunctionalized chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy. Int J Biol Macromol 205: 211-219.
85. Chetri, P.B., Shukla, R., Khan, J.M., Padhi, A.K., Seal, A., and Tripathi, T*. (2022) Unraveling the structural basis of urea-induced unfolding of Fasciola gigantica cytosolic malate dehydrogenase. J Mol Liq 349: 118170.
84. Singh, A., Patel, S.K., Kumar, P., Das, K.C., Verma, D., Sharma, R., Tripathi, T., Giri, R., Martins, N., and Garg, N. (2022) Quercetin act as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain. J Biomol Struct Dyn 40(10): 4507-4515.
83. Sasidharan, S., Tripathi, T*., and Saudagar, P. (2021) Critical insight into plausible acquired tocopherol pathway in neglected human trypanosomatids. ACS Omega 6(47): 31396-31403.
82. Padhi, A.K., Dandapat, J., Saudagar, P., Uversky, V.N. and Tripathi, T*. (2021) Interface-based design of the favipiravir-binding site in SARS-CoV-2 RNA-dependent RNA polymerase reveals mutations conferring resistance to chain termination. FEBS Lett 595(18): 2366-2382.
81. Padhi, A.K., Rath, S.L., and Tripathi, T*. (2021) Accelerating COVID-19 research using molecular dynamics simulation. J Phys Chem B 125(32): 9078-9091.
80. Padhi, A.K. and Tripathi, T*. (2021) Targeted design of drug binding sites in the main protease of SARS-CoV-2 reveals potential signatures of adaptation. Biochem Biophys Res Commun 555: 147-153.
79. Lyngdoh, D.L., Nag, N., Uversky, V.N. and Tripathi, T*. (2021) Prevalence and functionality of intrinsic disorder in human FG-nucleoporins. Int J Biol Macromol 175: 156-170.
78. Sasidharan, S., Gosu, V., Shin, D., Nath, S., Tripathi, T., and Saudagar, P. (2021) Therapeutic p28 peptide targets essential H1N1 Influenza virus proteins: Insights from docking and molecular dynamic simulations. Mol Divers 25(3): 1929-1943.
77. Padhi, A.K., Shukla, R., Saudagar, P. and Tripathi, T*. (2021) High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: Implications for potential resistance. iScience 24(1): 101992.
76. Padhi, A.K., Seal, A., Khan, J.M., Ahamed, M. and Tripathi, T*. (2021) Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations. Eur J Pharmacol 894: 173836.
75. Mishra, S.K. and Tripathi, T*. (2021) One year update on the COVID-19 pandemic: where are we now? Acta Trop 214: 105778.
74. Shukla, R., Shukla, H., and Tripathi, T*. (2021) Structure-based discovery of phenyl-diketo acids derivatives as Mycobacterium tuberculosis malate synthase inhibitors. J Biomol Struct Dyn 39(8): 2945-2958.
73. Yadav, S., Prakash, J., Shukla, H., Das, K.C., Tripathi, T. and Dubey, V.K. (2020) Design of a multi-epitope subunit vaccine for immune-protection against Leishmania parasite. Pathog Glob Health 114(8): 471-481.
72. Padhi, A.K., and Tripathi, T*. (2020) Can SARS-CoV-2 accumulate mutations in the S-protein to increase pathogenicity? ACS Pharmacol Transl Sci 3(5): 1023–1026.
71. Chetri, P.B., Shukla, R. and Tripathi, T*. (2020) Identification and characterization of cytosolic malate dehydrogenase from the liver fluke Fasciola gigantica. Sci Rep 10: 13372.
70. Kalita, J., Shukla, H. and Tripathi, T*. (2020) Engineering glutathione S-transferase with a point mutation at conserved F136 residue increases the xenobiotic-metabolizing activity. Int J Biol Macromol 163: 1117-1126.
69. Kalita, J., Padhi, A.K. and Tripathi, T*. (2020) Designing a vaccine for fascioliasis using immunogenic 24 kDa mu-class glutathione s-transferase. Infect Genet Evol 83:104352.
68. Tripathi, T*. (2020) A master regulator of α-synuclein aggregation. ACS Chem Neurosci 11(10): 1376-1378.
67. Kalita, P., Padhi, A.K., Zhang, K.Y.J. and Tripathi, T*. (2020) Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2. Microb Pathog 145: 104236.
66. Pandey, T., Ghosh, A., Todur, V.N., Rajendran, V., Kalita, P., Kalita, J., Shukla, R., Chetri, P.B., Shukla, H., Sonkar, A., Lyngdoh, D.L., Singh, R., Khan, H., Nongkhlaw, J., Das, K.C. and Tripathi, T*. (2020) Draft genome of the liver fluke Fasciola gigantica. ACS Omega 5(19): 11084-11091.
65. Tripathi, T*. and Chetri, P.B. (2020) Potent inhibitors of thioredoxin glutathione reductase: grail of anti-schistosome drug within reach? ACS Infect Dis 6(5): 893-895.
64. Das, K.C., Kalita, P. and Tripathi, T*. (2020) Genome-wide identification and characterization of eukaryotic protein kinases. Front Biosci (Landmark Ed) 25(9): 1787-1827.
63. Tripathi, T*. and Khan, H. (2020) Direct interaction between the β-amyloid core and tau facilitates cross-seeding: A novel target for therapeutic intervention. Biochemistry 59(4): 341-342.
62. Singh, S.K. and Tripathi, T*. (2020) Presence of collagen-like repeats in bacteriophage–encoded hyaluronate lyase. J Sci Res 64(1): 193-197.
61. Gupta, S., Shukla, H., Kumar, A., Shukla, R., Kumari, R., Tripathi, T., Singh, R.K. and Anupurba, S. (2020) Mycobacterium tuberculosis nucleoside diphosphate kinase shows interaction with putative ATP binding cassette (ABC) transporter, Rv1273c. J Biomol Struct Dyn 38(4): 1083-1093.
60. Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., and Bharadwaj, P. (2019) Autophagy modulation as a treatment of amyloid diseases. Molecules 24(18): 3372.
59. Kalita, P., Das, K.C., Shukla, H., and Tripathi, T*. (2019) Conserved Arg451 residue is critical for maintaining the stability and activity of thioredoxin glutathione reductase. Arch Biochem Biophys 674: 108098.
58. Kalita, P., Lyngdoh, D.L., Padhi, A.K., Shukla, H. and Tripathi, T*. (2019) Development of multi-epitope driven subunit vaccine against Fasciola gigantica using immunoinformatics approach. Int J Biol Macromol 138: 224-233.
57. Tripathi, T*., Kalita, P., Martins, R. and Bharadwaj, P. (2019) Autophagy promotes memory formation. ACS Chem Neurosci 10(8): 3337-3339.
56. Lyngdoh, D.L., Shukla, H., Sonkar, A., Anupam, R. and Tripathi, T*. (2019) Portrait of intrinsically disordered side of the HTLV-1 proteome. ACS Omega 4(6): 10003-10018.
55. Tripathi, T*. and Kalita, J. (2019) Abnormal microtubule dynamics impair the nuclear-cytoplasmic transport in dementia. ACS Chem Neurosci 10(3): 1133-1134.
54. Tripathi, T*. and Kalita, P. (2019) Synergistic effect of amyloid-β and tau disrupts neural circuits. ACS Chem Neurosci 10(3): 1129-1130.
53. Chetri, P.B., Shukla, R. and Tripathi, T*. (2019) Identification and characterization of glyceraldehyde 3-phosphate dehydrogenase from Fasciola gigantica. Parasitol Res 118: 861-872.
52. Tripathi, T*, Prakash, J. and Shav-Tal, Y. (2019) Phospho-tau impairs nuclear-cytoplasmic transport. ACS Chem Neurosci 10: 36-38.
51. Tripathi, T*. and Chattopadhyay, K. (2019) Interaction of α-synuclein with ATP synthase: Switching role from physiological to pathological. ACS Chem Neurosci 10(1): 16-17.
50. Namdev, P., Lyngdoh, D.L., Dar, H.Y., Chaurasiya, S.K., Srivastava, R., Tripathi, T. and Anupam, R. (2019) Intrinsically disordered human T lymphotropic virus type 1 p30 protein: Experimental and computational evidence. AIDS Res Hum Retrovirus 35(5): 477-487.
49. Sonkar, A., Shukla, H., Shukla, R., Kalita, J., and Tripathi, T*. (2019) Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate: A combined spectroscopic and computational investigation. Int J Biol Macromol 126: 941-951.
48. Kalita, J., Shukla, R. and Tripathi, T*. (2019) Structural basis of urea-induced unfolding of Fasciola gigantica glutathione S-transferase. J Cell Physiol 234(4): 4491-4503.
47. Shukla, R., Shukla, H. and Tripathi, T*. (2019) Structural and energetic understanding of novel natural inhibitors of Mycobacterium tuberculosis malate synthase. J Cell Biochem 120: 2469-2482.
46. Vijayakumar, R., Shukla, R., Shukla, H. and Tripathi, T*. (2018) Structure-function studies of the asparaginyl tRNA synthetase from Fasciola gigantica: Understanding the role of catalytic and non-catalytic domains. Biochem J 475(21): 3377-3391.
45. Kalita, P., Shukla, H., Gadhave, K., Giri, R. and Tripathi, T*. (2018) Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase. Arch Biochem Biophys 656: 38-45.
44. Dhasmana, D., Singh, A., Shukla, R., Tripathi, T. and Garg, N. (2018) Targeting nucleotide binding domain of P-glycoprotein for reversal of multi drug resistance in cancer. Sci Rep 8(1): 11973.
43. Sonkar, A., Lyngdoh, D., Shukla, R., Shukla, H., Tripathi, T*. and Ahmed, S. (2018) Point mutation A394E in the central intrinsic disordered region of Rna14 leads to chromosomal instability in fission yeast. Int J Biol Macromol 119: 785-791.
42. Shav-Tal, Y. and Tripathi, T*. (2018) Yeast and human nuclear pore complexes: Not so similar after all. Trends Cell Biol 28(8): 589-591.
41. Shukla, H., Khan, S.R., Shukla, R., Krishnan, M.Y., Akhtar, M.S. and Tripathi, T*. (2018) Alternate pathway to ascorbate induced inhibition of Mycobacterium tuberculosis. Tuberculosis 111: 161-169.
40. Chetri, P.B., Shukla, R., Pakharukova, M.Y., Mordvinov, V.A. and Tripathi, T*. (2018) Optimization of soluble expression, purification and preliminary characterization of cytochrome P450 of the liver fluke Opisthorchis felineus. J Protein Proteomics 9(2): 91-99.
39. Suttiprapa, S., Sotillo, J., Smout, M., Suyapoh, W., Chaiyade, S., Tripathi, T., Laha, T., Loukas, A. (2018) Opisthorchis viverrini proteome and host-parasite interactions. Adv Parasitol 102: 45-72.
38. Kalita, P., Shukla, H., Shukla, R. and Tripathi, T*. (2018) Biochemical and thermodynamic comparison of the selenocysteine containing and non-containing thioredoxin glutathione reductase of Fasciola gigantica. Biochim Biophys Acta Gen Subjects 1862(6): 1306-1316.
37. Verma, S., Kumar, A., Tripathi, T. and Kumar, A. (2018) Muscarinic and nicotinic acetylcholine receptor agonists: Current scenario in Alzheimer’s disease therapy. J Pharm Pharmacol 70: 985-993.
36. Shukla, R., Shukla, H., Kalita, P. and Tripathi, T*. (2018) Structural insights into natural compounds as inhibitors of Fasciola gigantica thioredoxin glutathione reductase. J Cell Biochem 119: 3067-3080.
35. Vijayakumar, R. Kalita, P., Shukla, H., Kumar, A. and Tripathi, T*. (2018) Aminoacyl-tRNA synthetases: structure, function, and drug discovery. Int J Biol Macromol 111: 400-414.
34. Shukla, R., Shukla, H. and Tripathi, T*. (2018) Activity loss by H46 mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site. Tuberculosis 108:143-150.
33. Vijayakumar, R. and Tripathi, T*. (2018) Soluble expression and purification of a full-length asparaginyl tRNA synthetase from Fasciola gigantica. Protein Expr Purif 143: 9-13.
32. Shukla, R., Chetri, P.B., Sonkar, A., Pakharukova, M.Y., Mordvinov, V.A. and Tripathi, T*. (2018) Identification of novel natural inhibitors of Opisthorchis felineus cytochrome P450 using structure-based screening and molecular dynamic simulation. J Biomol Struct Dyn 36(13): 3541-3556.
31. Shukla, R., Shukla, H., Kalita, P., Sonkar, A., Pandey, T., Singh, D.B., Kumar, A. and Tripathi, T*. (2018) Identification of potential inhibitors of Fasciola gigantica thioredoxin1: Computational screening, molecular dynamics simulation and binding free energy studies. J Biomol Struct Dyn 36(8): 2147-2162.
30. Shukla, R., Shukla, H., Sonkar, A., Pandey, T. and Tripathi, T*. (2018) Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase. J Biomol Struct Dyn 36(8): 2045-2057.
29. Kalita, J., Shukla, R., Shukla, H., Gadhave, K., Giri, R., and Tripathi, T*. (2017) Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica. Sci Rep 7(1): 17547.
28. Singh, A.K., Chettri, B., Ghosh, A., Chikara, S.K. and Tripathi, T*. (2017) Draft genome of Novosphingobium panipatense P5:ABC isolated from hydrocarbon-contaminated soil from noonmati refinery, Assam, India. Genome Announc 5: e01265-17.
27. Singh, A.K., Chettri, B., Ghosh, A., Chikara, S.K. and Tripathi, T*. (2017) Draft genome sequence of the hydrocarbon-degrading bacterium Acinetobacter pittii strain ABC isolated from noonmati refinery, Assam, India. Genome Announc 5: e01264-17.
26. Vimal, A., Pal, D., Tripathi, T*, and Kumar, A. (2017) Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of Salmonella target protein l-asparaginase. 3Biotech 7: 258.
25. Shukla, H., Shukla, R., Sonkar, A. and Tripathi, T*. (2017) Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase. Biochem Biophys Res Commun 490(2): 276-282.
24. Shukla, H., Kumar, R., Sonkar, A., Mitra, K., Akhtar, M.S. and Tripathi, T*. (2017) Salt-regulated reversible fibrillation of Mycobacterium tuberculosis isocitrate lyase: Concurrent restoration of structure and activity. Int J Biol Macromol 104: 89-96.
23. Shukla, H., Shukla, R., Sonkar, A., Pandey, T. and Tripathi, T*. (2017) Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility. Sci Rep 7(1): 1058.
22. Sonkar, A., Shukla, H., Shukla, R., Kalita, J., Pandey, T., and Tripathi, T*. (2017) UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties. Int J Biol Macromol 97: 106-114.
21. Pandey, T., Shukla, R., Shukla, H., Sonkar, A., Tripathi, T* and Singh, A.K. (2017) A combined biochemical and computational studies of the rho-class glutathione s-transferase sll1545 of Synechocystis PCC 6803. Int J Biol Macromol 94: 378-385.
20. Tripathi, T*, Suttiprapa, S. and Sripa, B. (2017) Unusual thiol-based redox metabolism of parasitic flukes. Parasitol Int 66: 390-395.
19. Gupta, A., Sripa, B. and Tripathi, T*. (2017) Purification and characterization of a two-domain glutaredoxin in the parasitic helminth Fasciola gigantica. Parasitol Int 66: 432-435.
18. Bharati, A.P., Singh, N., Kumar, V., Kashif, M., Singh, A.K., Singh, P., Singh, S.K., Siddiqui, M.I., Tripathi, T. and Akhtar, M.S. (2016) The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II. Sci Rep 6: 31294.
17. Gupta, A., Kesherwani, M., Velmurugan, D. and Tripathi, T*. (2016) Fasciola gigantica thioredoxin glutathione reductase: Biochemical properties and structural modeling. Int J Biol Macromol 89: 152-160.
16. Nisha, C.M., Kumar, A., Nair, P., Gupta, N., Silakari, C., Tripathi, T*. and Kumar A. (2016) Molecular docking and in silico ADMET study reveals acylguanidine 7a as a potential inhibitor of β-secretase. Adv Bioinformatics 9258578: doi.10.1155/2016/9258578.
15. Kumar, A., Nisha, C.M., Silakari, C., Sharma, I., Anusha, K., Gupta, N., Nair, P., Tripathi, T. and Kumar A. (2016) Current and novel therapeutic molecules and targets in Alzheimer’s disease. J Formos Med Assoc 115(1): 3-10.
14. Chhetri, G., Kalita, P. and Tripathi, T*. (2015) An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli. MethodsX 2: 385-391.
13. Gupta, A., Pandey, T., Kumar, B. and Tripathi, T*. (2015) Preferential regeneration of thioredoxin from parasitic flatworm Fasciola gigantica using glutathione system. Int J Biol Macromol 81: 983-990.
12. Chhetri. G., Pandey, T., Chinta, R., Kumar, A., and Tripathi, T*. (2015) An improved method for high-level soluble expression and purification of recombinant amyloid beta peptide for in vitro studies. Protein Expres Purif 114: 71-76.
11. Pandey, T., Singh, S.K., Chhetri, G, Tripathi, T* and Singh, A.K. (2015) Characterization of a highly pH stable Chi-class glutathione S-transferase from Synechocystis PCC 6803. PLoS One 10(5): e0126811.
10. Tripathi, T*. (2015) The N-terminal portion of the glutaredoxin like protein 1 of Plasmodium falciparum does not contribute to the stability of the enzyme. J Protein Proteomics 6(2): 153-158.
09. Pandey, T., Chhetri. G., Chinta, R., Kumar. B., Singh, D.B., Tripathi, T* and Singh, A.K. (2015) Functional classification and biochemical characterization of a novel rho class glutathione S-transferase in Synechocystis PCC 6803. FEBS Open Bio 5: 1-7.
08. Chhetri. G., Pandey, T., Kumar. B., Akhtar, M.S. and Tripathi, T*. (2015) Recombinant expression, purification and preliminary characterization of the mRNA export factor MEX67 of Saccharomyces cerevisiae. Protein Expres Purif 107: 56-61.
07. Chhetri. G., Ghosh. A., Chinta. R., Akhtar, M.S. and Tripathi, T*. (2015) Cloning, soluble expression, and purification of the RNA polymerase II subunit RPB5 from Saccharomyces cerevisiae. Bioengineered 6(1): 1-5.
06. Yogavel, M., Tripathi, T., Gupta, A., Bandey, M.M., Rahlfs, S., Becker, K., Belrhali, H., and Sharma, A. (2014) Atomic-resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other Grxs. Acta Crystallogr Sect D: Biol Crystallogr 70: 91-100.
05. Tripathi, T*. (2013) Calculation of thermodynamic parameters of protein unfolding using far-ultraviolet circular dichroism. J Proteins Proteomics 4(2): 85-91.
04. Tripathi, T., Roseler, A., Rahlfs, S., Becker, K., and Bhakuni, V. (2010) Conformational stability and energetics of Plasmodium falciparum glutaredoxin. Biochimie 92(3): 284-291.
03. Tripathi, T., Na, B.K., Sohn, W.M., Becker, K., and Bhakuni, V. (2009) Structural, functional and unfolding characteristics of glutathione S-transferase of Plasmodium vivax. Arch Biochem Biophys 487: 115–122.
02. Tripathi, T., Rahlfs, S., Becker, K., and Bhakuni, V. (2008) Structural and stability characteristics of a monothiol glutaredoxin: glutaredoxin-like protein 1 from Plasmodium falciparum. Biochim Biophys Acta Protein Proteom 1784: 946-952.
01. Tripathi, T., Rahlfs, S., Becker, K., and Bhakuni, V. (2007) Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase. BMC Struct Biol 7: 67.
Book Chapters:
20. Tripathi, T., Singh, D.B., and Tripathi, T*. (2024) Computational resources and chemoinformatics for translational health research. Adv Protein Chem Struct Biol Chapter 2, 139: 27-55. [ISBN: 978-0-4431-9348-4].
19. Kalita, P., Padhi, A.K., and Tripathi, T*. (2023) Immunoinformatics protocol to design multi-epitope subunit vaccines. In: Reche, P.A. (ed). Computational Vaccine Design. Methods Mol. Biol. Humana Press, USA. [ISBN: 978-1-0716-3238-3]. Chapter 25, 2673: 357-369.
18. Sasidharan, S., Shukla, R., Tripathi, T.*, and Saudagar, P. (2023) pH-based molecular dynamics simulation for analyzing protein structure and folding. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 11, Pp. 203-220.
17. Shukla, R., and Tripathi, T.* (2023) Investigating protein unfolding and stability using chaotropic agents and molecular dynamics simulation. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 10, Pp. 181-202.
16. Awasthi, N., Shukla, R., Kumar, D., Tiwari, A.K., and Tripathi, T.* (2023) Monte Carlo approaches to study protein conformation ensembles. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 7, Pp. 129-146.
15. Sasidharan, S., Gosu, V., Tripathi, T.*, and Saudagar, P. (2023) Molecular dynamics simulation to study protein conformation and ligand interaction. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 6, Pp. 107-128.
14. Banesh, S., Neharika, G., Reddy, C.V., Tripathi, T.*, and Saudagar, P. (2023) Applications of differential scanning calorimetry in studying folding and stability of proteins. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 3, Pp. 37-60.
13. Kumar, R., Tripathi, T.*, and Saudagar, P. (2023) Fluorescence spectroscopy-based methods to study protein folding dynamics. In Saudagar, P. & Tripathi, T. (eds) Protein Folding Dynamics and Stability: Experimental and Computational Methods. Springer Singapore. [ISBN: 978-981-99-2078-5]. Chapter 2, Pp. 25-36.
12. Sasidharan, S., Nag, N., Tripathi, T.*, and Saudagar, P. (2023) Interactions and interplay of MLOs with classical membrane-bound organelles. In: Uversky, V.N. (ed). Droplets of Life: Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation. Academic Press, USA. [ISBN: 978-012-82-3967-4]. P Chapter 12, p. 375-395.
11. Prince, K., Sasidharan, S., Nag, N., Tripathi, T.*, and Saudagar, P. (2023) Integration of spectroscopic and computational data to analyze protein structure, function, folding, and dynamics. In Saudagar, P. & Tripathi, T. (eds) Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics. Academic Press, USA. [ISBN: 978-032-39-9127-8]. Chapter 16, Pp. 483-520.
10. Sahu, R., Sooram, B., Sasidharan, S., Nag, N., Tripathi, T.*, and Saudagar, P. (2023) Applications of infrared spectroscopy to study proteins. In Saudagar, P. & Tripathi, T. (eds) Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics. Academic Press, USA. [ISBN: 978-032-39-9127-8]. Chapter 6, Pp. 153-178.
09. Nag, N., Sasidharan, S., and Saudagar, P., Tripathi, T.* (2023) Fundamentals of spectroscopy for biomolecular structure and dynamics. In Saudagar, P. & Tripathi, T. (eds) Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics. Academic Press, USA. Chapter 1, [ISBN: 978-032-39-9127-8]. Chapter 1, Pp. 1-35.
08. Nag, N., Chetri, P.B., Uversky, V.N., Giri, R., and Tripathi, T.* (2022) Experimental methods to study intrinsically disordered proteins. In: Tripathi, T. & Dubey, V.K. (eds) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. [ISBN: 978-032-39-0264-9]. Chapter 31, Pp. 505-533.
07. Kumar, P., Bhardwaj, A., Uversky, V.N., Tripathi, T., and Giri, R. (2022) Computational methods to study intrinsically disordered proteins. In: Tripathi, T. & Dubey, V.K. (eds) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. [ISBN: 978-032-39-0264-9]. Chapter 30, Pp. 489-504.
06. Sasidharan, S., Nag, N., Tripathi, T., and Saudagar, P. (2022) Experimental methods to study the thermodynamics of protein-protein interactions. In: Tripathi, T. & Dubey, V.K. (eds) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. [ISBN: 978-032-39-0264-9]. Chapter 7, Pp. 103-114.
05. Chetri, P.B., Khan, H., and Tripathi, T.* (2022) Methods to determine the oligomeric structure of proteins. In: Tripathi, T. & Dubey, V.K. (eds) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. [ISBN: 978-032-39-0264-9]. Chapter 5, Pp. 49-76.
04. Nag, N., Khan, H. and Tripathi, T.* (2022) Strategies to improve the expression and solubility of recombinant proteins in E. coli. In: Tripathi, T. & Dubey, V.K. (eds) Advances in Protein Molecular and Structural Biology Methods. Academic Press, USA. [ISBN: 978-032-39-0264-9]. Chapter 1, Pp. 1-12.
03. Shukla, R. and Tripathi, T*. (2021) Molecular dynamics simulation in drug discovery: opportunities and challenges. In: Singh, S.K. (eds) Innovations and Implementations of Drug Discovery Strategies in Rational Drug Design. Springer Singapore. [ISBN 978-981-15-8935-5]. Chapter 12, Pp. 295-316.
02. Shukla, R. and Tripathi, T*. (2020) Molecular dynamics simulation of protein and protein-ligand complexes. In: Singh, D.B. (eds) Computer-Aided Drug Design. Springer Singapore. [ISBN 978-981-15-6814-5]. Chapter 7, Pp. 133-161.
01. Shukla, H. and Tripathi, T*. (2018) Studying parasite gene function and interaction through ribozymes and riboswitches design mechanism. In: Singh, S. (eds) Synthetic Biology: Omics Tools and Their Applications. Springer Singapore. [ISBN 978-981-10-8692-2]. Chapter 4, Pp. 51-74.
* As Corresponding Author
Book Chapters in Hindi:
01. तिमिर तà¥Âरिपाठà¥? (2022). शिà¤?à¥Âषा नà¥?ति 2020 à¤?र à¤?नà¥Âसà¤?धान. समà¥Âपादà¤?: डा. à¤?तà¥Âल à¤?à¥?ठारà¥?. राषà¥Âà¤?à¥Âरà¥?य शिà¤?à¥Âषा नà¥?ति 2022: à¤à¤¾à¤°à¤¤à¥?यता à¤?ा पà¥Âनरà¥Âतà¥Âथान. पà¥Âरà¤à¤¾à¤¤ पà¥Âरà¤?ाशन, नà¤? दिलà¥Âलà¥? Pp. 159-164.
Research Contacts:
2024, North-Eastern Hill University
Designed & developed at Bioinformatics Centre, NEHU
